Full Product Name
GNMT (Glycine N-methyltransferase)
Product Synonym Names
Anti -GNMT (Glycine N-methyltransferase)
Product Gene Name
anti-GNMT antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
MVDSVYRTRS LGVAAEGLPD QYADGEAARV WQLYIGDTRS RTAEYKAWLL GLLRQHGCQR VLDVACGTGV DSIMLVEEGF SVTSVDASDK MLKYALKERW NRRHEPAFDK WVIEEANWMT LDKDVPQSAE GGFDAVICLG NSFAHLPDCK GDQSEHRLAL KNIASMVRAG GLLVIDHRNY DHILSTGCAP PGKNIYYKSD LTKDVTTSVL IVNNKAHMVT LDYTVQVPGA GQDGSPGLSK FRLSYYPHCL ASFTELLQAA FGGKCQHSVL GDFKPYKPGQ TYIPCYFIHV LKRTD
Chromosome Location
Chromosome: 6; NC_000006.11 (42928500..42931618). Location: 6p12
3D Structure
ModBase 3D Structure for Q14749
Specificity
Recognizes human GNMT.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Immunogen
Full length human GNMT, aa1-295 (NP_061833.1).
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-GNMT antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-GNMT antibody
Glycine N-methyltransferase (GNMT) catalyzes the synthesis of N-methylglycine (sarcosine) from glycine using S-adenosylmethionine (AdoMet) as the methyl donor. GNMT acts as an enzyme to regulate the ratio of S-adenosylmethionine to S-adenosylhomocysteine (AdoHcy) and participates in the detoxification pathway in liver cells.
Product Categories/Family for anti-GNMT antibody
Antibodies; Abs to Enzymes, Methyltransferase
Applications Tested/Suitable for anti-GNMT antibody
Western Blot (WB)
Application Notes for anti-GNMT antibody
Suitable for use in Western Blot.
NCBI/Uniprot data below describe general gene information for GNMT. It may not necessarily be applicable to this product.
NCBI Accession #
NP_061833.1
[Other Products]
NCBI GenBank Nucleotide #
NM_018960.4
[Other Products]
UniProt Primary Accession #
Q14749
[Other Products]
UniProt Secondary Accession #
Q5T8W2; Q9NNZ1; Q9NS24[Other Products]
UniProt Related Accession #
Q14749[Other Products]
Molecular Weight
32,742 Da[Similar Products]
NCBI Official Full Name
glycine N-methyltransferase
NCBI Official Synonym Full Names
glycine N-methyltransferase
NCBI Official Symbol
GNMT [Similar Products]
NCBI Protein Information
glycine N-methyltransferase
UniProt Protein Name
Glycine N-methyltransferase
Protein Family
Glycine N-methyltransferase
UniProt Gene Name
GNMT [Similar Products]
UniProt Entry Name
GNMT_HUMAN
NCBI Summary for GNMT
The protein encoded by this gene is an enzyme that catalyzes the conversion of S-adenosyl-L-methionine (along with glycine) to S-adenosyl-L-homocysteine and sarcosine. The encoded protein is found in the cytoplasm and acts as a homotetramer. Defects in this gene are a cause of GNMT deficiency (hypermethioninemia). [provided by RefSeq, Oct 2008]
UniProt Comments for GNMT
GNMT: Catalyzes the methylation of glycine by using S- adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine. Defects in GNMT are the cause of glycine N- methyltransferase deficiency (GNMT deficiency); also known as hypermethioninemia. The only clinical abnormalities in patients with this deficiency are mild hepatomegaly and chronic elevation of serum transaminases. Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family.
Protein type: EC 2.1.1.20; Amino Acid Metabolism - glycine, serine and threonine; Methyltransferase
Chromosomal Location of Human Ortholog: 6p12
Cellular Component: cytoplasm
Molecular Function: protein binding; glycine N-methyltransferase activity; glycine binding; folic acid binding
Biological Process: methylation; glycogen metabolic process; S-adenosylmethionine metabolic process; protein modification process; methionine metabolic process; regulation of gluconeogenesis; one-carbon compound metabolic process; protein homotetramerization
Disease: Glycine N-methyltransferase Deficiency
Research Articles on GNMT
1. single-nucleotide polymorphisms in VEGF, IL-10 and GNMT genes might have a synergistic role in the development of Prostate cancer
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
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