Full Product Name
STAT6 antibody
Product Synonym Names
Rabbit polyclonal STAT6 antibody; Polyclonal STAT6 antibody; Anti-STAT6 antibody; STAT6C antibody; IL-4-STAT antibody; STAT 6; STAT-6; Signal transducer and activator of transcription 6 antibody; STAT 6 antibody; STAT6; Phospho Thr645 antibody; STAT-6 antibody; D12S1644 antibody; STAT6B antibody
Product Gene Name
anti-STAT6 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Purity/Purification
Purified by immunoaffinity chromatography.
Form/Format
Liquid form in PBS buffer (no MG2+ or Ca2+), pH 7.4, 150 mm NaCl,0.02% sodium azide and 50% glycerol.
Concentration
1 mg/ml (lot specific)
Immunogen
STAT6 antibody was raised in Rabbit using the peptide sequence around phosphorylation site of threonine 645 (P-A-T(p)-I-K) derived from Human STAT6 as the immunogen.
Preparation and Storage
Store at 4 degree C for short term storage.
Aliquot and store at-20 degree C for long term storage.
Avoid repeated freeze/thaw cycles.
Other Notes
Small volumes of anti-STAT6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-STAT6 antibody
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo-or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated
biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins.
Product Categories/Family for anti-STAT6 antibody
DNA & RNA
Applications Tested/Suitable for anti-STAT6 antibody
Immunohistochemistry (IHC)
Application Notes for anti-STAT6 antibody
IHC: 1:50-1:100
Immunohistochemistry (IHC) of anti-STAT6 antibody
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using STAT6 (Phospho-Thr645) antibody (left) or the same antibody preincubated with with blocking peptide (right)
NCBI/Uniprot data below describe general gene information for STAT6. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001171552.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001178081.1
[Other Products]
UniProt Secondary Accession #
Q5FBW5; Q71UP4; A8K316; B7ZA27; F5GXI9[Other Products]
UniProt Related Accession #
P42226[Other Products]
Molecular Weight
81,748 Da
NCBI Official Full Name
signal transducer and activator of transcription 6 isoform 2
NCBI Official Synonym Full Names
signal transducer and activator of transcription 6
NCBI Official Symbol
STAT6 [Similar Products]
NCBI Official Synonym Symbols
STAT6B; STAT6C; D12S1644; IL-4-STAT
[Similar Products]
NCBI Protein Information
signal transducer and activator of transcription 6
UniProt Protein Name
Signal transducer and activator of transcription 6
UniProt Synonym Protein Names
IL-4 Stat
Protein Family
Signal transducer and transcription activator
UniProt Gene Name
STAT6 [Similar Products]
NCBI Summary for STAT6
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
UniProt Comments for STAT6
Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling.
Research Articles on STAT6
1. Results of our structure-function studies on STAT6 shed light on mechanism of DNA recognition by STATs in general and explain the reasons underlying STAT6's preference for N4 site DNA over N3.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
