TXNDC3, Polyclonal Antibody

Anti -TXNDC3 (Thioredoxin Domain-containing Protein 3, CILD6, NM23-H8, NME/NM23 Family Member 8, NME8, Spermatid-specific Thioredoxin-2, SPTRX2, Sptrx-2)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 7; NC_000007.13 (37887930..37940003). Location: 7p14.1

Polyclonal

IgG

Mouse

Recognizes human TXNDC3.

Affinity Purified
Purified by Protein A affinity chromatography.

Supplied as a liquid in PBS, pH 7.2.

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Small volumes of anti-NME8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Antibodies; Abs to Thioredoxin

Western Blot (WB), Immunofluorescence (IF)

Suitable for use in Immunofluorescence and Western Blot.
Dilution: Immunofluorescence: 10ug/ml

67,270 Da[Similar Products]

NME/NM23 family member 8

thioredoxin domain-containing protein 3; sperm-specific thioredoxin 2; spermatid-specific thioredoxin-2; thioredoxin domain containing 3 (spermatozoa)

Thioredoxin domain-containing protein 3

SPTRX2; TXNDC3; Sptrx-2  [Similar Products]

TXND3_HUMAN

This gene encodes a protein with an N-terminal thioredoxin domain and three C-terminal nucleoside diphosphate kinase (NDK) domains, but the NDK domains are thought to be catalytically inactive. The sea urchin ortholog of this gene encodes a component of sperm outer dynein arms, and the protein is implicated in ciliary function. Mutations in this gene are implicated in primary ciliary dyskinesia type 6.[provided by RefSeq, Nov 2009]

TXNDC3: Probably required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs. May be involved in the reduction of disulfide bonds within the sperm FS components. In vitro, it has neither NDP kinase nor reducing activity on disulfide bonds. Defects in NME8 are the cause of primary ciliary dyskinesia type 6 (CILD6). CILD is an autosomal recessive disorder characterized by axonemal abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia; reduced fertility is often observed in male patients due to abnormalities of sperm tails. Half of the patients exhibit situs inversus, due to dysfunction of monocilia at the embryonic node and randomization of left-right body asymmetry. Primary ciliary dyskinesia associated with situs inversus is referred to as Kartagener syndrome.

Protein type: Kinase, nucleoside diphosphate; Oxidoreductase; Other group; NDK family

Chromosomal Location of Human Ortholog: 7p14.1

Cellular Component: cytoplasm; intracellular

Molecular Function: nucleoside diphosphate kinase activity; ATP binding

Biological Process: GTP biosynthetic process; CTP biosynthetic process; cell redox homeostasis; multicellular organismal development; UTP biosynthetic process; nucleoside diphosphate phosphorylation; spermatogenesis; cell differentiation

Disease: Ciliary Dyskinesia, Primary, 6

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