2',5'-Oligoadenylate Synthetase, Polyclonal Antibody

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

The antibody is a rabbit polyclonal antibody raised against OAS1. It has beenselected for its ability to recognize OAS1 in immunohistochemical staining andwestern blotting.

Affinity Chromatography

Liquid

200ug/ml (lot specific)

Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.

Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.

Small volumes of anti-OAS1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA)

Western blotting: 0.5-5ug/mL
Immunohistochemistry: 5-20ug/mL
Immunocytochemistry: 5-20ug/mL
Optimal working dilutions must be determined by end user.

Western Blot: Sample: Rat Stomach Tissue.

Western Blot: Sample: Recombinant OAS1, Rat.

DAB staining on IHC-P; Samples: Rat Large Intestine Tissue.

DAB staining on IHC-P; Samples: Rat Liver Tissue

DAB staining on IHC-P; Samples: Rat Lung Tissue.

41,666 Da

2'-5' oligoadenylate synthetase 1A

2'-5'-oligoadenylate synthase 1A

2'-5'-oligoadenylate synthase 1A

Oas1; (2-5')oligo(A) synthase 1A; 2-5A synthase 1A  [Similar Products]

plays a role in interferon-induced antiviral response [RGD, Feb 2006]

OAS1: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. The secreted form displays antiviral effect against vesicular stomatitis virus (VSV), herpes simplex virus type 2 (HSV-2), and encephalomyocarditis virus (EMCV) and stimulates the alternative antiviral pathway independent of RNase L. Belongs to the 2-5A synthase family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.7.7.84; Transferase

Chromosomal Location of Human Ortholog: 12q16

Cellular Component: endoplasmic reticulum; mitochondrion; nucleus

Molecular Function: 2'-5'-oligoadenylate synthetase activity; ATP binding; double-stranded RNA binding; metal ion binding; nucleotidyltransferase activity

Biological Process: defense response to virus; immune response; innate immune response; purine nucleotide biosynthetic process; response to virus

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