Full Product Name
CD171/N-CAML1 (Phospho-Ser1181) Antibody
Product Synonym Names
CAML; CAML1; CD171 antigen; L1CAM; MIC5; Neural cell adhesion molecule L1 precursor
Product Gene Name
anti-CD171/N-CAML1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P32004
Species Reactivity
Human, Mouse, Rat
Specificity
CD171/N-CAML1 (Phospho-Ser1181) antibody detects endogenous levels of CD171/N-CAML1 only when phosphorylated at serine 1181.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
The antiserum was produced against synthesized phosphopeptide derived from human CD171/N-CAML1 around the phosphorylation site of serine 1181 (L-E-SP-D-N).
All Sites
Human: Ser1181
Mouse: Ser1184
Rat: Ser1183
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-CD171/N-CAML1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-CD171/N-CAML1 antibody
Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
Applications Tested/Suitable for anti-CD171/N-CAML1 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-CD171/N-CAML1 antibody
WB: 1:500~1:1000
ELISA: 1:20000
Western Blot (WB) of anti-CD171/N-CAML1 antibody
Western blot analysis of extracts from K562 cells, using CD171/N-CAML1 (Phospho-Ser1181) antibody.
NCBI/Uniprot data below describe general gene information for CD171/N-CAML1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000416.1
[Other Products]
NCBI GenBank Nucleotide #
NM_000425.4
[Other Products]
UniProt Primary Accession #
P32004
[Other Products]
UniProt Secondary Accession #
Q8TA87; A0AV65; A4ZYW4; B2RMU7; G3XAF4[Other Products]
UniProt Related Accession #
P32004[Other Products]
Molecular Weight
138,908 Da
NCBI Official Full Name
neural cell adhesion molecule L1 isoform 1
NCBI Official Synonym Full Names
L1 cell adhesion molecule
NCBI Official Symbol
L1CAM [Similar Products]
NCBI Official Synonym Symbols
S10; HSAS; MASA; MIC5; SPG1; CAML1; CD171; HSAS1; N-CAML1; NCAM-L1; N-CAM-L1
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NCBI Protein Information
neural cell adhesion molecule L1
UniProt Protein Name
Neural cell adhesion molecule L1
UniProt Synonym Protein Names
CD_antigen: CD171
UniProt Gene Name
L1CAM [Similar Products]
UniProt Synonym Gene Names
CAML1; MIC5; N-CAM-L1; NCAM-L1 [Similar Products]
NCBI Summary for CD171/N-CAML1
The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause X-linked neurological syndromes known as CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of this gene results in multiple transcript variants, some of which include an alternate exon that is considered to be specific to neurons. [provided by RefSeq, May 2013]
UniProt Comments for CD171/N-CAML1
Neural cell adhesion molecule involved in the dynamics of cell adhesion and in the generation of transmembrane signals at tyrosine kinase receptors. During brain development, critical in multiple processes, including neuronal migration, axonal growth and fasciculation, and synaptogenesis. In the mature brain, plays a role in the dynamics of neuronal structure and function, including synaptic plasticity.
Product References and Citations for anti-CD171/N-CAML1 antibody
Yves Allory, Clin. Cancer Res., Feb 2005; 11: 1190-1197. David Mason, Blood, May 2002; 99: 3877-3880. Jussuf T. Kaifi, AACR Meeting Abstracts, Apr 2005; 2005: 289. Paul Gutwein, Clin. Cancer Res., Apr 2005; 11: 2492-2501.
Research Articles on CD171/N-CAML1
1. data make L1CAM a highly interesting therapeutic target to prevent further metastatic spread in melanoma patients
Precautions
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Disclaimer
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