ECE-1, Blocking Peptide

Endothelin-converting enzyme 1; ECE-1; ECE1

For Research Use Only. Not for use in diagnostic procedures.

The synthetic peptide sequence used to generate the antibody was selected from the C-term region of human ECE-1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Small volumes of ECE1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Converts big endothelin-1 to endothelin-1.

87,022 Da

endothelin converting enzyme 1

endothelin-converting enzyme 1

Endothelin-converting enzyme 1

ECE-1  [Similar Products]

ECE1_HUMAN

The protein encoded by this gene is involved in proteolytic processing of endothelin precursors to biologically active peptides. Mutations in this gene are associated with Hirschsprung disease, cardiac defects and autonomic dysfunction. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Sep 2009]

ECE1: Converts big endothelin-1 to endothelin-1. Defects in ECE1 are a cause of Hirschsprung disease cardiac defects and autonomic dysfunction (HSCRCDAD). It is a form of Hirschsprung disease with skip-lesions defects, craniofacial abnormalities and other dysmorphic features, and autonomic dysfunction. Belongs to the peptidase M13 family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.24.71; Protease; Vesicle; Membrane protein, integral; Cell surface

Chromosomal Location of Human Ortholog: 1p36.1

Cellular Component: endosome; external side of plasma membrane; integral to membrane; lysosomal membrane; membrane; perinuclear region of cytoplasm; vesicle

Molecular Function: endopeptidase activity; metalloendopeptidase activity; peptide hormone binding; protein binding; protein homodimerization activity

Biological Process: ear development; embryonic digit morphogenesis; heart development; hormone catabolic process; peptide hormone processing; positive regulation of receptor recycling; protein processing; regulation of systemic arterial blood pressure by endothelin; regulation of vasoconstriction

Disease: Hirschsprung Disease, Cardiac Defects, And Autonomic Dysfunction; Hypertension, Essential

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