ECE1, Polyclonal Antibody

ECE

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Antigen affinity purification

1.8mg/mL (lot specific)

Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

Manufactured in an ISO 9001:2015 Certified Laboratory.

Small volumes of anti-ECE1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

The protein encoded by this gene is involved in proteolytic processing of endothelin precursors to biologically active peptides. Mutations in this gene are associated with Hirschsprung disease, cardiac defects and autonomic dysfunction. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

ELISA (EIA), Western Blot (WB)

WB: 1:1000-1:5000

Western Blot analysis of Mouse heart tissue using ECE1 Polyclonal Antibody at dilution of 1:900

87,022 Da

endothelin converting enzyme 1

endothelin-converting enzyme 1; ECE-1

Endothelin-converting enzyme 1

ECE-1  [Similar Products]

ECE1_HUMAN

The protein encoded by this gene is involved in proteolytic processing of endothelin precursors to biologically active peptides. Mutations in this gene are associated with Hirschsprung disease, cardiac defects and autonomic dysfunction. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Sep 2009]

ECE1: Converts big endothelin-1 to endothelin-1. Defects in ECE1 are a cause of Hirschsprung disease cardiac defects and autonomic dysfunction (HSCRCDAD). It is a form of Hirschsprung disease with skip-lesions defects, craniofacial abnormalities and other dysmorphic features, and autonomic dysfunction. Belongs to the peptidase M13 family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Protease; EC 3.4.24.71; Vesicle; Cell surface; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p36.1

Cellular Component: membrane; perinuclear region of cytoplasm; lysosomal membrane; early endosome; plasma membrane; integral to membrane; endosome; vesicle; external side of plasma membrane

Molecular Function: protein homodimerization activity; metalloendopeptidase activity; metal ion binding; peptide hormone binding; endopeptidase activity

Biological Process: pharyngeal system development; regulation of systemic arterial blood pressure by endothelin; heart development; regulation of vasoconstriction; peptide hormone processing; ear development; hormone catabolic process; protein processing; embryonic digit morphogenesis; proteolysis; positive regulation of receptor recycling

Disease: Hirschsprung Disease, Cardiac Defects, And Autonomic Dysfunction; Hypertension, Essential

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