Full Product Name
XK antibody - N-terminal region
Product Gene Name
anti-XK antibody
[Similar Products]
Product Synonym Gene Name
KX; X1k; XKR1; MCLDS[Similar Products]
Antibody/Peptide Pairs
XK peptide (MBS3226733) is used for blocking the activity of XK antibody (MBS3201729)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
Synthetic peptide located within the following region: LHLLQLGPLF RCFEVFCIYF QSGNNEEPYV SITKKRQMPK NGLSEEIEKE
3D Structure
ModBase 3D Structure for P51811
Species Reactivity
Cow, Dog, Guinea Pig, Human, Mouse, Rabbit, Rat
Purity/Purification
Affinity Purified
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Homology
Cow: 100%; Dog: 85%; Guinea Pig: 85%; Human: 100%; Mouse: 100%; Rabbit: 85%; Rat: 100%
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human XK
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-XK antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-XK antibody
This is a rabbit polyclonal antibody against XK. It was validated on Western Blot using a cell lysate as a positive control.
Target Description: This locus controls the synthesis of the Kell blood group 'precursor substance' (Kx). Mutations in this gene have been associated with McLeod syndrome, an X-linked, recessive disorder characterized by abnormalities in the neuromuscular and hematopoietic systems. XK has structural characteristics of prokaryotic and eukaryotic membrane transport proteins.This locus controls the synthesis of the Kell blood group 'precursor substance' (Kx). Mutations in this gene have been associated with McLeod syndrome, an X-linked, recessive disorder characterized by abnormalities in the neuromuscular and hematopoietic systems. The encoded protein has structural characteristics of prokaryotic and eukaryotic membrane transport proteins. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Product Categories/Family for anti-XK antibody
Polyclonal; Signal Proteins; Membrane Protein; Membrane & Traffic; Disease Related;
Applications Tested/Suitable for anti-XK antibody
Western Blot (WB)
Western Blot (WB) of anti-XK antibody
WB Suggested Anti-XK Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:12500
Positive Control: MCF7 cell lysate
NCBI/Uniprot data below describe general gene information for XK. It may not necessarily be applicable to this product.
NCBI Accession #
NP_066569
[Other Products]
NCBI GenBank Nucleotide #
NM_021083
[Other Products]
UniProt Primary Accession #
P51811
[Other Products]
UniProt Related Accession #
P51811[Other Products]
NCBI Official Full Name
membrane transport protein XK
NCBI Official Synonym Full Names
X-linked Kx blood group
NCBI Official Symbol
XK [Similar Products]
NCBI Official Synonym Symbols
KX; NA; NAC; X1k; XKR1
[Similar Products]
NCBI Protein Information
membrane transport protein XK
UniProt Protein Name
Membrane transport protein XK
UniProt Synonym Protein Names
Kell complex 37 kDa component; Kx antigen; XK-related protein 1
Protein Family
XK-related protein
UniProt Gene Name
XK [Similar Products]
UniProt Synonym Gene Names
XKR1; XRG1 [Similar Products]
UniProt Entry Name
XK_HUMAN
NCBI Summary for XK
This locus controls the synthesis of the Kell blood group 'precursor substance' (Kx). Mutations in this gene have been associated with McLeod syndrome, an X-linked, recessive disorder characterized by abnormalities in the neuromuscular and hematopoietic systems. The encoded protein has structural characteristics of prokaryotic and eukaryotic membrane transport proteins. [provided by RefSeq, Jul 2008]
UniProt Comments for XK
XK: May be involved in sodium-dependent transport of neutral amino acids or oligopeptides. Defects in XK are the cause of McLeod syndrome (MLS). It is an X-linked multisystem disorder characterized by late onset abnormalities in the neuromuscular and hematopoietic systems. Belongs to the XK family.
Protein type: Cell surface; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: Xp21.1
Cellular Component: integral to membrane
Molecular Function: protein binding; transporter activity
Biological Process: myelination; cellular calcium ion homeostasis; transport; amino acid transport; regulation of axon diameter; skeletal muscle fiber development; regulation of cell size
Disease: Mcleod Syndrome
Research Articles on XK
1. the expression of KX is critical to normal morphology, and null mutations are associated with the McLeod neuroacanthocytosis syndrome.
Precautions
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Disclaimer
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