Product Name
Chimaerin alpha 2 (CHN1), Blocking Peptide
Full Product Name
N-Chimaerin Antibody Antigenic Blocking Peptide
Product Synonym Names
A-chimaerin; Alpha-chimerin; ARHGAP2; CHN; Chn1; N chimaerin; NC; Rho GTPase-activating protein 2; RHOGAP2 antibody
Product Gene Name
CHN1 blocking peptide
[Similar Products]
Antibody/Peptide Pairs
Chimaerin alpha 2 peptide (MBS542843) is used for blocking the activity of Chimaerin alpha 2 antibody (MBS541253)
Antibody/Peptide Pairs
Chimaerin alpha 2 peptide (MBS542843) is used for blocking the activity of Chimaerin alpha 2 antibody (MBS541254)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P15882
Form/Format
Antigenic Blocking Peptide
Concentration
Quantity: 250 ug; Volume: 100 ul (lot specific)
Immunogen
Synthetic Peptide
Expression
In neurons in brain regions that are involved in learning and memory processes.
Molecular Function
GTPase activation
Structure
Interacts with EPHA4; effector of EPHA4 in axon guidance linking EPHA4 activation to RAC1 regulation.
Subcellular Location
Cytosol
Preparation and Storage
-20 degree C for long term storage
Other Notes
Small volumes of CHN1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
CHN1 blocking peptide
Antigenic Blocking Peptide N-Chimaerin isoform 1 Antibody
GTPase-activating protein for p21-rac and a phorbol ester receptor. Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance.
Applications Tested/Suitable for CHN1 blocking peptide
Immunodepletion, Immunocompetition Assay
Application Notes for CHN1 blocking peptide
Western Blot: 1:500
NCBI/Uniprot data below describe general gene information for CHN1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001813
[Other Products]
NCBI GenBank Nucleotide #
NM_001822.5
[Other Products]
UniProt Primary Accession #
P15882
[Other Products]
UniProt Secondary Accession #
Q53SD6; Q53SH5; Q96FB0; A8K1M6; B3KNU6; B4DV19[Other Products]
UniProt Related Accession #
P15882[Other Products]
Molecular Weight
50,034 Da[Similar Products]
NCBI Official Full Name
N-chimaerin isoform 1
NCBI Official Synonym Full Names
chimerin 1
NCBI Official Symbol
CHN1 [Similar Products]
NCBI Official Synonym Symbols
NC; CHN; DURS2; ARHGAP2; RHOGAP2
[Similar Products]
NCBI Protein Information
N-chimaerin
UniProt Protein Name
N-chimaerin
UniProt Synonym Protein Names
A-chimaerin; Alpha-chimerin; N-chimerin; NC; Rho GTPase-activating protein 2
Protein Family
N-chimaerin
UniProt Gene Name
CHN1 [Similar Products]
UniProt Synonym Gene Names
ARHGAP2; CHN; NC [Similar Products]
UniProt Entry Name
CHIN_HUMAN
NCBI Summary for CHN1
This gene encodes GTPase-activating protein for ras-related p21-rac and a phorbol ester receptor. It is predominantly expressed in neurons, and plays an important role in neuronal signal-transduction mechanisms. Mutations in this gene are associated with Duane's retraction syndrome 2 (DURS2). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011]
UniProt Comments for CHN1
ARHGAP2: GTPase-activating protein for p21-rac and a phorbol ester receptor. Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance. Interacts with EPHA4; effector of EPHA4 in axon guidance linking EPHA4 activation to RAC1 regulation. In neurons in brain regions that are involved in learning and memory processes. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: GAPs; GAPs, Rac/Rho; Adaptor/scaffold
Chromosomal Location of Human Ortholog: 2q31.1
Cellular Component: cytoplasm; cytosol
Molecular Function: ephrin receptor binding; GTPase activator activity; metal ion binding; protein binding; SH3/SH2 adaptor activity
Biological Process: ephrin receptor signaling pathway; motor axon guidance; positive regulation of GTPase activity; positive regulation of signal transduction; regulation of axonogenesis; regulation of GTPase activity; regulation of small GTPase mediated signal transduction
Disease: Duane Retraction Syndrome 2
Research Articles on CHN1
1. Stimulation of mesenchymal stromal cells (MSCs) by chemerin increases phosphorylation of p42/44, p38 and JNK-II kinases and inhibitors of these kinases and PKC reverse chemerin-stimulated MSC migration.
Precautions
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Disclaimer
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