Full Product Name
ITPR1 Antibody, Biotin conjugated
Product Synonym Names
Inositol 1; 4; 5-trisphosphate receptor type 1; IP3 receptor isoform 1; IP3R 1; InsP3R1; Type 1 inositol 1; 4; 5-trisphosphate receptor; Type 1 InsP3 receptor; ITPR1; INSP3R1
Product Gene Name
anti-ITPR1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q14643
Purity/Purification
>95%, Protein G purified
Immunogen
Recombinant Human Inositol 1, 4, 5-trisphosphate receptor type 1 protein (1707-1966AA)
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Preparation and Storage
Upon receipt, store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-ITPR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ITPR1 antibody
Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1, 4, 5-trisphosphate (PubMed:27108797). Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (By similarity). Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity).
Product Categories/Family for anti-ITPR1 antibody
Cancer; Metabolism; Signal transduction
Applications Tested/Suitable for anti-ITPR1 antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for ITPR1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001093422.2
[Other Products]
NCBI GenBank Nucleotide #
NM_001099952.2
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UniProt Primary Accession #
Q14643
[Other Products]
UniProt Secondary Accession #
Q14660; Q99897; E7EPX7; E9PDE9[Other Products]
UniProt Related Accession #
Q14643[Other Products]
Molecular Weight
309,338 Da
NCBI Official Full Name
inositol 1,4,5-trisphosphate receptor type 1 isoform 1
NCBI Official Synonym Full Names
inositol 1,4,5-trisphosphate receptor type 1
NCBI Official Symbol
ITPR1 [Similar Products]
NCBI Official Synonym Symbols
ACV; CLA4; IP3R; IP3R1; SCA15; SCA16; SCA29; INSP3R1; PPP1R94
[Similar Products]
NCBI Protein Information
inositol 1,4,5-trisphosphate receptor type 1
UniProt Protein Name
Inositol 1,4,5-trisphosphate receptor type 1
UniProt Synonym Protein Names
IP3 receptor isoform 1; IP3R 1; InsP3R1; Type 1 inositol 1,4,5-trisphosphate receptor; Type 1 InsP3 receptor
Protein Family
Inositol 1,4,5-trisphosphate receptor
UniProt Gene Name
ITPR1 [Similar Products]
UniProt Synonym Gene Names
INSP3R1; IP3R 1; InsP3R1; Type 1 InsP3 receptor [Similar Products]
NCBI Summary for ITPR1
This gene encodes an intracellular receptor for inositol 1,4,5-trisphosphate. Upon stimulation by inositol 1,4,5-trisphosphate, this receptor mediates calcium release from the endoplasmic reticulum. Mutations in this gene cause spinocerebellar ataxia type 15, a disease associated with an heterogeneous group of cerebellar disorders. Multiple transcript variants have been identified for this gene. [provided by RefSeq, Nov 2009]
UniProt Comments for ITPR1
Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate (PubMed:27108797). Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (). Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways ().
Research Articles on ITPR1
1. study broadens the mutational spectrum of ITPR1 and also emphasizes the importance of considering ITPR1 mutations as a potential cause of inherited cerebellar ataxias
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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