Full Product Name
CHN1 antibody - middle region
Product Gene Name
anti-CHN1 antibody
[Similar Products]
Product Synonym Gene Name
ARHGAP2; CHN; RHOGAP2; NC; DURS2[Similar Products]
Antibody/Peptide Pairs
CHN1 peptide (MBS3235494) is used for blocking the activity of CHN1 antibody (MBS3210539)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
Synthetic peptide located within the following region: KVYSCDLTTL VKAHTTKRPM VVDMCIREIE SRGLNSEGLY RVSGFSDLIE
3D Structure
ModBase 3D Structure for P15882
Species Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Yeast, Zebrafish
Purity/Purification
Affinity Purified
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Homology
Cow: 93%; Dog: 86%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 100%; Yeast: 77%; Zebrafish: 86%
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human CHN1
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-CHN1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CHN1 antibody
This is a rabbit polyclonal antibody against CHN1. It was validated on Western Blot using a cell lysate as a positive control.
Target Description: CHN1 contains 1 phorbol-ester/DAG-type zinc finger, 1 Rho-GAP domain and 1 SH2 domain. CHN1 is a GTPase-activating protein for p21-rac and a phorbol ester receptor. It may play an important role in neuronal signal-transduction mechanisms.
Product Categories/Family for anti-CHN1 antibody
Polyclonal; Lymphocyte Signaling; Neuroscience; Signal Transduction;
Applications Tested/Suitable for anti-CHN1 antibody
Western Blot (WB)
Western Blot (WB) of anti-CHN1 antibody
WB Suggested Anti-CHN1 Antibody Titration: 0.2-1 ug/ml
Positive Control: Jurkat cell lysate
NCBI/Uniprot data below describe general gene information for CHN1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001813
[Other Products]
NCBI GenBank Nucleotide #
NM_001822
[Other Products]
UniProt Primary Accession #
P15882
[Other Products]
UniProt Related Accession #
P15882[Other Products]
NCBI Official Full Name
N-chimaerin isoform 1
NCBI Official Synonym Full Names
chimerin 1
NCBI Official Symbol
CHN1 [Similar Products]
NCBI Official Synonym Symbols
NC; CHN; DURS2; ARHGAP2; RHOGAP2
[Similar Products]
NCBI Protein Information
N-chimaerin
UniProt Protein Name
N-chimaerin
UniProt Synonym Protein Names
A-chimaerin; Alpha-chimerin; N-chimerin; NC; Rho GTPase-activating protein 2
Protein Family
N-chimaerin
UniProt Gene Name
CHN1 [Similar Products]
UniProt Synonym Gene Names
ARHGAP2; CHN; NC [Similar Products]
UniProt Entry Name
CHIN_HUMAN
NCBI Summary for CHN1
This gene encodes GTPase-activating protein for ras-related p21-rac and a phorbol ester receptor. It is predominantly expressed in neurons, and plays an important role in neuronal signal-transduction mechanisms. Mutations in this gene are associated with Duane's retraction syndrome 2 (DURS2). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011]
UniProt Comments for CHN1
ARHGAP2: GTPase-activating protein for p21-rac and a phorbol ester receptor. Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance. Interacts with EPHA4; effector of EPHA4 in axon guidance linking EPHA4 activation to RAC1 regulation. In neurons in brain regions that are involved in learning and memory processes. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: GAPs; Adaptor/scaffold; GAPs, Rac/Rho
Chromosomal Location of Human Ortholog: 2q31.1
Cellular Component: cytosol
Molecular Function: SH3/SH2 adaptor activity; ephrin receptor binding; metal ion binding; GTPase activator activity
Biological Process: regulation of small GTPase mediated signal transduction; positive regulation of signal transduction; small GTPase mediated signal transduction; ephrin receptor signaling pathway; motor axon guidance; regulation of axonogenesis; positive regulation of GTPase activity
Disease: Duane Retraction Syndrome 2
Research Articles on CHN1
1. CHN1 mutations were identified in 2 bilateral cases and in 1 parent of 1 affected case. One mutation is novel and occurred with additional vertical gaze abnormalities.
Precautions
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