Product Name
SDHAF1, Blocking Peptide
Full Product Name
SDHAF1 Peptide
Product Synonym Names
LYRM8; LYRM8; Succinate dehydrogenase assembly factor 1; mitochondrial; LYR motif-containing protein 8; SDH assembly factor 1; succinate dehydrogenase complex assembly factor 1
Product Gene Name
SDHAF1 blocking peptide
[Similar Products]
SDHAF1 peptide (MBS154081) is used for blocking the activity of SDHAF1 antibody (MBS150667)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for A6NFY7
Concentration
200 ug/mL (lot specific)
Buffer
PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
Location
18 amino acids near the carboxy terminus of human SDHAF1.
Preparation and Storage
Store SDHAF1 peptide at -20 degree C, stable for one year.
Other Notes
Small volumes of SDHAF1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for SDHAF1 blocking peptide
Blocking (BL)
Application Notes for SDHAF1 blocking peptide
SDHAF1 peptide is used for blocking the activity of SDHAF1 antibody.
NCBI/Uniprot data below describe general gene information for SDHAF1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001036096
[Other Products]
NCBI GenBank Nucleotide #
NM_001042631.2
[Other Products]
UniProt Primary Accession #
A6NFY7
[Other Products]
UniProt Secondary Accession #
B2RPM7[Other Products]
UniProt Related Accession #
A6NFY7[Other Products]
Molecular Weight
12,806 Da
NCBI Official Full Name
succinate dehydrogenase assembly factor 1, mitochondrial
NCBI Official Synonym Full Names
succinate dehydrogenase complex assembly factor 1
NCBI Official Symbol
SDHAF1 [Similar Products]
NCBI Official Synonym Symbols
LYRM8
[Similar Products]
NCBI Protein Information
succinate dehydrogenase assembly factor 1, mitochondrial; SDH assembly factor 1; LYR motif containing 8; LYR motif-containing protein 8
UniProt Protein Name
Succinate dehydrogenase assembly factor 1, mitochondrial
UniProt Synonym Protein Names
LYR motif-containing protein 8
UniProt Gene Name
SDHAF1 [Similar Products]
UniProt Synonym Gene Names
SDHAF1 [Similar Products]
UniProt Entry Name
SDHF1_HUMAN
NCBI Summary for SDHAF1
The succinate dehydrogenase (SDH) complex (or complex II) of the mitochondrial respiratory chain is composed of 4 individual subunits. The protein encoded by this gene resides in the mitochondria, and is essential for SDH assembly, but does not physically associate with the complex in vivo. Mutations in this gene are associated with SDH-defective infantile leukoencephalopathy (mitochondrial complex II deficiency).[provided by RefSeq, Mar 2010]
UniProt Comments for SDHAF1
SDHAF1: Plays an essential role in succinate dehydrogenase complex (SDH) assembly, a complex involved in complex II of the mitochondrial electron transport chain. Probably acts by participating in mitochondrial biosynthesis of iron-sulfur centers for complex II (Probable). Defects in SDHAF1 are a cause of mitochondrial complex II deficiency (MT-C2D); also known as SDH-defective infantile leukoencephalopathy. A disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations. Clinical features include psychomotor regression in infants, poor growth with lack of speech development, severe spastic quadriplegia, dystonia, progressive leukoencephalopathy, muscle weakness, exercise intolerance, cardiomyopathy. Some patients manifest Leigh syndrome or Kearns-Sayre syndrome. Belongs to the complex I LYR family. SDHAF1 subfamily.
Chromosomal Location of Human Ortholog: 19q13.12
Cellular Component: mitochondrion; mitochondrial matrix
Biological Process: iron-sulfur cluster assembly
Disease: Mitochondrial Complex Ii Deficiency
Research Articles on SDHAF1
1. Studies indicate that an array of tumor syndromes caused by complex II-associated mutations in genes SDHA, SDHB, SDHC, SDHD, SDHAF1 and SDHAF2 have been identified over a decade.
Precautions
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Disclaimer
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