CHN1, Blocking Peptide

For Research Use Only. Not for use in diagnostic procedures.

Lyophilized powder

Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20 degree C. Avoid repeat freeze-thaw cycles.

Small volumes of CHN1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This is a synthetic peptide designed for use in combination with anti-CHN1 antibody made

Target Description: CHN1 contains 1 phorbol-ester/DAG-type zinc finger, 1 Rho-GAP domain and 1 SH2 domain. CHN1 is a GTPase-activating protein for p21-rac and a phorbol ester receptor. It may play an important role in neuronal signal-transduction mechanisms.

Peptide

Western Blot (WB)

53kDa

chimerin 1

N-chimaerin

N-chimaerin

ARHGAP2; CHN; NC  [Similar Products]

CHIN_HUMAN

This gene encodes GTPase-activating protein for ras-related p21-rac and a phorbol ester receptor. It is predominantly expressed in neurons, and plays an important role in neuronal signal-transduction mechanisms. Mutations in this gene are associated with Duane's retraction syndrome 2 (DURS2). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011]

ARHGAP2: GTPase-activating protein for p21-rac and a phorbol ester receptor. Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance. Interacts with EPHA4; effector of EPHA4 in axon guidance linking EPHA4 activation to RAC1 regulation. In neurons in brain regions that are involved in learning and memory processes. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: GAPs; Adaptor/scaffold; GAPs, Rac/Rho

Chromosomal Location of Human Ortholog: 2q31.1

Cellular Component: cytosol

Molecular Function: SH3/SH2 adaptor activity; ephrin receptor binding; metal ion binding; GTPase activator activity

Biological Process: regulation of small GTPase mediated signal transduction; positive regulation of signal transduction; small GTPase mediated signal transduction; ephrin receptor signaling pathway; motor axon guidance; regulation of axonogenesis; positive regulation of GTPase activity

Disease: Duane Retraction Syndrome 2

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