Product Name
Cholinergic Receptor, Nicotinic, Alpha 3 (CHRNa3), Antibody Pair Kit
Full Product Name
Cholinergic Receptor, Nicotinic, Alpha 3 (CHRNa3) Antibody Pair Kit (with Standard)
Product Synonym Names
CHR-NA3; CHRN-A3; N-AChRA3; NAChRA3; N-AChR-A3; Neuronal Acetylcholine Receptor Alpha 3
Product Gene Name
CHRNa3 antibody pair kit
[Similar Products]
Matching Pairs
Antibody: Cholinergic Receptor, Nicotinic, Alpha 3 (CHRNa3) (MBS2102329)
Pairing: Cholinergic Receptor, Nicotinic, Alpha 3 (CHRNa3) (MBS2102329)
Comments: Matched antibody pair kit containing antibody/standard combination
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Request for Current Manual Insert
Request Current Manual
Samples
Tissue Homogenates and Other Biological Fluids
Detection Range
0.625-40ng/mL
Standard
Recombinant CHRNa3 (Lyophilized, 1 vial-10ug)
Capture Antibody
Rabbit polyclonal antibody (Liquid, 1 vial-400mug/800muL)
Detection Antibody
Biotinylated Rabbit polyclonal antibody (Liquid, 1 vial-100mug/500muL)
Producte Usage
Raw materials can be used for preparation of 5x96T or 10x96T ELISA Kits.
Antibody Support Pack
Antibody Support Pack (Buffer Pack) is sold separately as catalog #MBS2090685
ISO Certification
Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customerâs specifications, please inquire.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
Other Notes
Small volumes of CHRNa3 antibody pair kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for CHRNa3 antibody pair kit
Neuro science
Applications Tested/Suitable for CHRNa3 antibody pair kit
ELISA (EIA), Chemiluminescence Immunoassays (CLIA), ELISPOT, Luminex
NCBI/Uniprot data below describe general gene information for CHRNa3. It may not necessarily be applicable to this product.
NCBI Accession #
AAH98443.1
[Other Products]
UniProt Secondary Accession #
Q15823; Q4KMN8; Q86U77; Q96RH3; Q99553; Q9BQ93; Q9BRR4[Other Products]
UniProt Related Accession #
P32297[Other Products]
Molecular Weight
55,637 Da
NCBI Official Full Name
Cholinergic receptor, nicotinic, alpha 3
NCBI Official Synonym Full Names
cholinergic receptor nicotinic alpha 3 subunit
NCBI Official Symbol
CHRNA3 [Similar Products]
NCBI Official Synonym Symbols
LNCR2; PAOD2; NACHRA3
[Similar Products]
NCBI Protein Information
neuronal acetylcholine receptor subunit alpha-3
UniProt Protein Name
Neuronal acetylcholine receptor subunit alpha-3
Protein Family
Neuronal acetylcholine receptor
UniProt Gene Name
CHRNA3 [Similar Products]
UniProt Synonym Gene Names
NACHRA3 [Similar Products]
NCBI Summary for CHRNa3
This locus encodes a member of the nicotinic acetylcholine receptor family of proteins. Members of this family of proteins form pentameric complexes comprised of both alpha and beta subunits. This locus encodes an alpha-type subunit, as it contains characteristic adjacent cysteine residues. The encoded protein is a ligand-gated ion channel that likely plays a role in neurotransmission. Polymorphisms in this gene have been associated with an increased risk of smoking initiation and an increased susceptibility to lung cancer. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2009]
UniProt Comments for CHRNa3
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Research Articles on CHRNa3
1. The rs13180 (IREB2), rs16969968 (CHRNA5) and rs1051730 (CHRNA3) were significantly associated with Chronic obstructive pulmonary disease (COPD) in additive model [Padj =0.00001, odds ratio (OR)=0.64; Padj =0.0001, OR=1.41 and Padj =0.0001, OR=1.47]. The C-G haplotype by rs13180 and rs1051730 was a protective factor for COPD in our population (Padj =0.0005, OR=0.61).
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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