Product Name
Phospho-Chimaerin beta 2 (CHN1), Polyclonal Antibody
Full Product Name
Phospho-Chimaerin beta 2 Antibody BIOTIN-Conjugated
Product Synonym Names
A-chimaerin; ARHGAP2; CHN; Chn1; N chimaerin; NC; Rho GTPase-activating protein 2; RHOGAP2 antibody
Product Gene Name
anti-CHN1 antibody
[Similar Products]
Matching Pairs
Antibody: Phospho-Chimaerin beta 2 (MBS542847)
Positive Control: Phospho-Chimaerin beta 2 (MBS543052)
Antibody/Peptide Pairs
Phospho-Chimaerin beta 2 peptide (MBS544141) is used for blocking the activity of Phospho-Chimaerin beta 2 antibody (MBS542847)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P15882
Species Reactivity
Human, Mouse, Rat
Form/Format
BIOTIN-Conjugated
Concentration
0.58-0.63 ug/ul in antibody stabilization buffer (lot specific)
Immunogen
Phosphorylated synthetic peptide corresponding to unique amino acid sequence on beta 2 Chimaerin protein.
Expression
In neurons in brain regions that are involved in learning and memory processes.
Modification
Phosphorylated
Molecular Function
GTPase activation
Structure
Interacts with EPHA4; effector of EPHA4 in axon guidance linking EPHA4 activation to RAC1 regulation.
Subcellular Location
Cytosol
Preparation and Storage
-20 degree C for long term storage
Other Notes
Small volumes of anti-CHN1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CHN1 antibody
BIOTIN-Conjugated Phosphorylated N-Chimaerin isoform 1 Antibody
GTPase-activating protein for p21-rac and a phorbol ester receptor. Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance.
Applications Tested/Suitable for anti-CHN1 antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-CHN1 antibody
Dot Blot: 1:10,000
ELISA: 1:10,000
Western Blot: 1:500
NCBI/Uniprot data below describe general gene information for CHN1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001813
[Other Products]
NCBI GenBank Nucleotide #
NM_001822.5
[Other Products]
UniProt Primary Accession #
P15882
[Other Products]
UniProt Secondary Accession #
Q53SD6; Q53SH5; Q96FB0; A8K1M6; B3KNU6; B4DV19[Other Products]
UniProt Related Accession #
P15882[Other Products]
Molecular Weight
50,034 Da[Similar Products]
NCBI Official Full Name
N-chimaerin isoform 1
NCBI Official Synonym Full Names
chimerin 1
NCBI Official Symbol
CHN1 [Similar Products]
NCBI Official Synonym Symbols
NC; CHN; DURS2; ARHGAP2; RHOGAP2
[Similar Products]
NCBI Protein Information
N-chimaerin
UniProt Protein Name
N-chimaerin
UniProt Synonym Protein Names
A-chimaerin; Alpha-chimerin; N-chimerin; NC; Rho GTPase-activating protein 2
Protein Family
N-chimaerin
UniProt Gene Name
CHN1 [Similar Products]
UniProt Synonym Gene Names
ARHGAP2; CHN; NC [Similar Products]
UniProt Entry Name
CHIN_HUMAN
NCBI Summary for CHN1
This gene encodes GTPase-activating protein for ras-related p21-rac and a phorbol ester receptor. It is predominantly expressed in neurons, and plays an important role in neuronal signal-transduction mechanisms. Mutations in this gene are associated with Duane's retraction syndrome 2 (DURS2). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011]
UniProt Comments for CHN1
ARHGAP2: GTPase-activating protein for p21-rac and a phorbol ester receptor. Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance. Interacts with EPHA4; effector of EPHA4 in axon guidance linking EPHA4 activation to RAC1 regulation. In neurons in brain regions that are involved in learning and memory processes. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: GAPs, Rac/Rho; Adaptor/scaffold; GAPs
Chromosomal Location of Human Ortholog: 2q31.1
Cellular Component: cytoplasm; cytosol
Molecular Function: ephrin receptor binding; GTPase activator activity; metal ion binding; protein binding; SH3/SH2 adaptor activity
Biological Process: ephrin receptor signaling pathway; motor axon guidance; positive regulation of GTPase activity; positive regulation of signal transduction; regulation of axonogenesis; regulation of GTPase activity; regulation of small GTPase mediated signal transduction
Disease: Duane Retraction Syndrome 2
Research Articles on CHN1
1. Stimulation of mesenchymal stromal cells (MSCs) by chemerin increases phosphorylation of p42/44, p38 and JNK-II kinases and inhibitors of these kinases and PKC reverse chemerin-stimulated MSC migration.
Precautions
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Disclaimer
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