Full Product Name
GLDC Antibody - C-terminal region
Product Gene Name
anti-GLDC antibody
[Similar Products]
Product Synonym Gene Name
GCE; GCSP; HYGN1[Similar Products]
Antibody/Peptide Pairs
GLDC peptide (MBS3236534) is used for blocking the activity of GLDC antibody (MBS3211585)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
Synthetic peptide located within the following region: ANIEAVDVAK RLQDYGFHAP TMSWPVAGTL MVEPTESEDK AELDRFCDAM
3D Structure
ModBase 3D Structure for P23378
Species Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
Purity/Purification
Affinity purified
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Homology
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%
Immunogen
The immunogen is a synthetic peptide directed towards the C-terminal region of Human GCSP
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-GLDC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-GLDC antibody
This is a rabbit polyclonal antibody against GCSP. It was validated on Western Blot
Target Description: Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the P protein, which binds to glycine and enables the methylamine group from glycine to be transferred to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH).
Product Categories/Family for anti-GLDC antibody
Polyclonal; Mitochondria; Disease Related;
Applications Tested/Suitable for anti-GLDC antibody
Western Blot (WB)
Western Blot (WB) of anti-GLDC antibody
Host: Rabbit
Target Name: GCSP
Sample Type: HCT15 Whole Cell lysates
Antibody Dilution: 1.0ug/ml
NCBI/Uniprot data below describe general gene information for GLDC. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000161
[Other Products]
NCBI GenBank Nucleotide #
NM_000170.2
[Other Products]
UniProt Primary Accession #
P23378
[Other Products]
UniProt Related Accession #
P23378[Other Products]
NCBI Official Full Name
glycine dehydrogenase (decarboxylating), mitochondrial
NCBI Official Synonym Full Names
glycine decarboxylase
NCBI Official Symbol
GLDC [Similar Products]
NCBI Official Synonym Symbols
GCE; GCSP; HYGN1
[Similar Products]
NCBI Protein Information
glycine dehydrogenase (decarboxylating), mitochondrial
UniProt Protein Name
Glycine dehydrogenase (decarboxylating), mitochondrial
UniProt Synonym Protein Names
Glycine cleavage system P protein; Glycine decarboxylase; Glycine dehydrogenase (aminomethyl-transferring)
UniProt Gene Name
GLDC [Similar Products]
UniProt Synonym Gene Names
GCSP [Similar Products]
UniProt Entry Name
GCSP_HUMAN
NCBI Summary for GLDC
Degradation of glycine is brought about by the glycine cleavage system, which is composed of four mitochondrial protein components: P protein (a pyridoxal phosphate-dependent glycine decarboxylase), H protein (a lipoic acid-containing protein), T protein (a tetrahydrofolate-requiring enzyme), and L protein (a lipoamide dehydrogenase). The protein encoded by this gene is the P protein, which binds to glycine and enables the methylamine group from glycine to be transferred to the T protein. Defects in this gene are a cause of nonketotic hyperglycinemia (NKH).[provided by RefSeq, Jan 2010]
Research Articles on GLDC
1. A novel compound heterozygous variant was identified in the GLDC gene in a Chinese family with non-ketotic hyperglycinemia
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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