Full Product Name
Rabbit TTF2 Antibody
Product Gene Name
anti-TTF2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 9; NC_000009.11 (100615537..100618997). Location: 9q22
3D Structure
ModBase 3D Structure for O00358
Species Reactivity
Human, mouse, rat
Form/Format
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
Concentration
1 mg/ml (lot specific)
Other Notes
Small volumes of anti-TTF2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-TTF2 antibody
ELISA (EIA), Western Blot (WB)
NCBI/Uniprot data below describe general gene information for TTF2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_004464.2
[Other Products]
NCBI GenBank Nucleotide #
NM_004473.3
[Other Products]
UniProt Primary Accession #
O00358
[Other Products]
UniProt Secondary Accession #
O75765; Q5T109; Q99526[Other Products]
UniProt Related Accession #
O00358[Other Products]
Molecular Weight
38,076 Da
NCBI Official Full Name
forkhead box protein E1
NCBI Official Synonym Full Names
forkhead box E1 (thyroid transcription factor 2)
NCBI Official Symbol
FOXE1 [Similar Products]
NCBI Official Synonym Symbols
TTF2; FOXE2; HFKH4; HFKL5; TITF2; TTF-2; FKHL15
[Similar Products]
NCBI Protein Information
forkhead box protein E1; forkhead box E2; forkhead box protein E2; HNF-3/fork head-like protein 5; thyroid transcription factor 2; forkhead-related protein FKHL15; forkhead, drosophila, homolog-like 15
UniProt Protein Name
Forkhead box protein E1
UniProt Synonym Protein Names
Forkhead box protein E2; Forkhead-related protein FKHL15; HFKH4; HNF-3/fork head-like protein 5; HFKL5; Thyroid transcription factor 2
Protein Family
Transcription termination factor
UniProt Gene Name
FOXE1 [Similar Products]
UniProt Synonym Gene Names
FKHL15; FOXE2; TITF2; TTF2; HFKL5; TTF-2 [Similar Products]
UniProt Entry Name
FOXE1_HUMAN
NCBI Summary for TTF2
This intronless gene belongs to the forkhead family of transcription factors, which is characterized by a distinct forkhead domain. This gene functions as a thyroid transcription factor which likely plays a crucial role in thyroid morphogenesis. Mutations in this gene are associated with congenital hypothyroidism and cleft palate with thyroid dysgenesis. The map localization of this gene suggests it may also be a candidate gene for squamous cell epithelioma and hereditary sensory neuropathy type I. [provided by RefSeq, Jul 2008]
UniProt Comments for TTF2
FOXE1: Probable transcription factor. Could be involved in thyroid gland organogenesis. Defects in FOXE1 are the cause of Bamforth-Lazarus syndrome (BLS). BLS is associated with thyroid agenesis, cleft palate and choanal atresia.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 9q22
Cellular Component: nucleus
Molecular Function: DNA binding; sequence-specific DNA binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; anatomical structure morphogenesis; cell migration; hair follicle morphogenesis; thymus development; positive regulation of transcription, DNA-dependent; thyroid hormone generation; negative regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; embryonic organ morphogenesis; hard palate development; thyroid gland development; soft palate development; negative regulation of transcription, DNA-dependent
Disease: Hypothyroidism, Athyroidal, With Spiky Hair And Cleft Palate; Thyroid Cancer, Nonmedullary, 4
Research Articles on TTF2
1. study showed evidence of association between forkhead box E1 (FOXE1) variants and thyroid cancer risk in the Portuguese population
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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