Full Product Name
TTF2 Antibody
Product Gene Name
anti-TTF2 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O00358
Other Notes
Small volumes of anti-TTF2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for TTF2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_004464.2
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NCBI GenBank Nucleotide #
NM_004473.3
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UniProt Primary Accession #
O00358
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UniProt Secondary Accession #
O75765; Q5T109; Q99526[Other Products]
UniProt Related Accession #
O00358[Other Products]
Molecular Weight
38,076 Da
NCBI Official Full Name
forkhead box protein E1
NCBI Official Synonym Full Names
forkhead box E1
NCBI Official Symbol
FOXE1 [Similar Products]
NCBI Official Synonym Symbols
TTF2; FOXE2; HFKH4; HFKL5; NMTC4; TITF2; TTF-2; FKHL15
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NCBI Protein Information
forkhead box protein E1
UniProt Protein Name
Forkhead box protein E1
UniProt Synonym Protein Names
Forkhead box protein E2; Forkhead-related protein FKHL15; HFKH4; HNF-3/fork head-like protein 5; HFKL5; Thyroid transcription factor 2; TTF-2
Protein Family
Transcription termination factor
UniProt Gene Name
FOXE1 [Similar Products]
UniProt Synonym Gene Names
FKHL15; FOXE2; TITF2; TTF2; HFKL5; TTF-2 [Similar Products]
NCBI Summary for TTF2
This intronless gene encodes a protein that belongs to the forkhead family of transcription factors. Members of this family contain a conserved 100-amino acid DNA-binding 'forkhead' domain. The encoded protein functions as a thyroid transcription factor that plays a role in thyroid morphogenesis. Mutations in this gene are associated with the Bamforth-Lazarus syndrome, and with susceptibility to nonmedullary thyroid cancer-4. [provided by RefSeq, Nov 2016]
UniProt Comments for TTF2
Transcription factor that binds consensus sites on a variety of gene promoters and activate their transcription. Involved in proper palate formation, most probably through the expression of MSX1 and TGFB3 genes which are direct targets of this transcription factor. Also implicated in thyroid gland morphogenesis. May indirectly play a role in cell growth and migration through the regulation of WNT5A expression.
Research Articles on TTF2
1. Report that PTCSC2 binds myosin-9 (MYH9). In a bidirectional promoter shared by FOXE1 and PTCSC2, MYH9 inhibits the promoter activity in both directions. This inhibition can be reversed by PTCSC2, which acts as a suppressor.
Precautions
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Disclaimer
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