Product Name
CACNG2, cDNA Clone
Full Product Name
CACNG2 cDNA Clone
Product Gene Name
CACNG2 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atggggctgt ttgatcgagg tgttcaaatg cttttaacca ccgttggtgc tttcgctgcc ttcagcctga tgaccatagc tgtgggaacc gactattggc tctactccag aggggtttgc aagaccaaaa gtgtcagtga gaatgaaacc agcaaaaaga acgaggaagt tatgacccat tccggattat ggagaacctg ctgcctagaa gggaatttca aaggtctgtg caagcaaatt gatcacttcc cagaggatgc agattacgaa gctgacacag cagaatattt cctccgggcc gtgagggcct ccagcatttt cccaatcctg agtgtgattc tgcttttcat gggtggcctc tgcatcgcag ccagcgagtt ctacaaaact cgacacaaca tcatcctgag tgccggcatc ttcttcgtgt ctgcaggtct gagtaacatc attggcatca tagtgtacat atctgccaat gccggagacc cctccaagag cgactccaaa aagaatagtt actcatacgg ctggtccttc tacttcgggg ccctgtcctt catcatcgcc gagatggtcg gggtgctggc ggtgcacatg tttatcgacc ggcacaaaca gctgcgggcc acggcccgcg ccacggacta cctccaggcc tctgccatca cccgcatccc cagctaccgc taccgctacc agcgccgcag ccgctccagc tcgcgctcca cggagccctc acactccagg gacgcctccc ccgtgggcat caagggcttc aacaccctgc cgtccacgga gatctccatg tacacgctca gcagggaccc cctgaaggcc gccaccacgc ccaccgccac ctacaactcc gacagggata acagcttcct ccaggttcac aactgtatcc agaaggagaa caaggactct ctccactcca acacagccaa ccgccggacc acccccgtat aa
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of CACNG2 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for CACNG2. It may not necessarily be applicable to this product.
NCBI Accession #
BC069612
[Other Products]
UniProt Secondary Accession #
Q2M1M1; Q5TGT3; Q9UGZ7[Other Products]
UniProt Related Accession #
Q9Y698[Other Products]
Molecular Weight
35,966 Da
NCBI Official Full Name
Homo sapiens calcium channel, voltage-dependent, gamma subunit 2, mRNA
NCBI Official Synonym Full Names
calcium voltage-gated channel auxiliary subunit gamma 2
NCBI Official Symbol
CACNG2 [Similar Products]
NCBI Official Synonym Symbols
MRD10
[Similar Products]
NCBI Protein Information
voltage-dependent calcium channel gamma-2 subunit
UniProt Protein Name
Voltage-dependent calcium channel gamma-2 subunit
UniProt Synonym Protein Names
Neuronal voltage-gated calcium channel gamma-2 subunit; Transmembrane AMPAR regulatory protein gamma-2; TARP gamma-2
Protein Family
Voltage-dependent calcium channel
UniProt Gene Name
CACNG2 [Similar Products]
UniProt Synonym Gene Names
TARP gamma-2 [Similar Products]
UniProt Entry Name
CCG2_HUMAN
NCBI Summary for CACNG2
The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family. This gene is a susceptibility locus for schizophrenia. [provided by RefSeq, Dec 2010]
UniProt Comments for CACNG2
Stargazin: Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Interacts with the PDZ domains of DLG4/PSD-95 and DLG1/SAP97. May interact with GOPC. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8. Interacts with GRIA1. Brain. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.
Protein type: Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 22q13.1
Cellular Component: plasma membrane
Molecular Function: calcium channel activity; channel regulator activity; protein binding
Biological Process: membrane depolarization; transmission of nerve impulse; transport
Disease: Mental Retardation, Autosomal Dominant 10
Research Articles on CACNG2
1. A transient positive feedback mechanism between AMPAR and stargazin has implications for information processing in the brain, because it should allow activity-dependent facilitation of excitatory synaptic transmission through a postsynaptic mechanism.
Precautions
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Disclaimer
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