CACNG2, Polyclonal Antibody

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Affinity Purification

1mg/mL (lot specific)

Store at -20 degree C. Avoid freeze / thaw cycles.

Manufactured in an ISO 9001:2015 Certified Laboratory.

Small volumes of anti-CACNG2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

CACNG2 (Calcium Voltage-Gated Channel Auxiliary Subunit Gamma 2) is a Protein Coding gene. Diseases associated with CACNG2 include Mental Retardation, Autosomal Dominant 10 and Autosomal Dominant Non-Syndromic Intellectual Disability. Among its related pathways are PEDF Induced Signaling and DREAM Repression and Dynorphin Expression. GO annotations related to this gene include voltage-gated calcium channel activity and ionotropic glutamate receptor binding. An important paralog of this gene is CACNG3.The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. The AMPA subtype of ionotropic glutamate receptors are ligand gated ion channels that are typically activated by glutamate released from presynaptic neuron terminals and mediate fast neurotransmission in excitatory synapses. TARPs thus play an important role in synaptic plasticity, learning and memory. Mutations in this gene cause the disorder autosomal dominant mental retardation-10 (MRD10).

Western Blot (WB), Immunohistochemistry (IHC) Paraffin

WB: 1:1000-2000
IHC: 1:200-500

Western Blot analysis of 1) Human brain, 2) Mouse brain, 3) Rat brain using CACNG2 Polyclonal Antibody at dilution of 1:20000.

Immunohistochemistry of paraffin-embedded Rat brain tissue with CACNG2 Polyclonal Antibody.

36kDa

calcium voltage-gated channel auxiliary subunit gamma 2

voltage-dependent calcium channel gamma-2 subunit

Voltage-dependent calcium channel gamma-2 subunit

TARP gamma-2  [Similar Products]

The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. The AMPA subtype of ionotropic glutamate receptors are ligand gated ion channels that are typically activated by glutamate released from presynaptic neuron terminals and mediate fast neurotransmission in excitatory synapses. TARPs thus play an important role in synaptic plasticity, learning and memory. Mutations in this gene cause an autosomal dominant form of cognitive disability. [provided by RefSeq, Jul 2017]

Stargazin: Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. The L-type calcium channel is composed of five subunits: alpha-1, alpha-2/delta, beta and gamma. Interacts with the PDZ domains of DLG4/PSD-95 and DLG1/SAP97. May interact with GOPC. Acts as an auxiliary subunit for AMPA-selective glutamate receptors (AMPARs). Found in a complex with GRIA1, GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8. Interacts with GRIA1. Brain. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.

Protein type: Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 22q12.3

Cellular Component: cell junction; neuron projection; plasma membrane; postsynaptic density membrane; somatodendritic compartment; voltage-gated calcium channel complex

Molecular Function: calcium channel activity; channel regulator activity; ionotropic glutamate receptor binding; protein binding; voltage-gated calcium channel activity

Biological Process: membrane depolarization; membrane hyperpolarization; neuromuscular junction development; neurotransmitter receptor transport, postsynaptic endosome to lysosome; postsynaptic neurotransmitter receptor diffusion trapping; regulation of AMPA receptor activity; transmission of nerve impulse; transport

Disease: Mental Retardation, Autosomal Dominant 10

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