Product Name
CFHL1 (CFHR1), Blocking Peptide
Full Product Name
CFHL1 Antibody (C-term) Blocking Peptide
Product Synonym Names
Complement factor H-related protein 1; FHR-1; H factor-like protein 1; H-factor-like 1; H36; CFHR1; CFHL; CFHL1; CFHL1P; CFHR1P; FHR1; HFL1; HFL2
Product Gene Name
CFHR1 blocking peptide
[Similar Products]
Product Synonym Gene Name
CFHL; CFHL1; CFHL1P; CFHR1P; FHR1; HFL1[Similar Products]
Antibody/Peptide Pairs
CFHL1 peptide (MBS9226201) is used for blocking the activity of CFHL1 antibody (MBS9204437)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q03591
Specificity
The synthetic peptide sequence used to generate the antibody was selected from the C-term region of human CFHL1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Cellular Location
Secreted.
Tissue Location
Expressed by the liver and secreted in plasma.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Other Notes
Small volumes of CFHR1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
CFHR1 blocking peptide
Involved in complement regulation. The dimerized forms have avidity for tissue-bound complement fragments and efficiently compete with the physiological complement inhibitor CFH. Can associate with lipoproteins and may play a role in lipid metabolism.
NCBI/Uniprot data below describe general gene information for CFHR1. It may not necessarily be applicable to this product.
NCBI Accession #
Q03591.2
[Other Products]
UniProt Primary Accession #
Q03591
[Other Products]
UniProt Secondary Accession #
Q3B774; Q9UJ17; A8K465[Other Products]
UniProt Related Accession #
Q03591[Other Products]
Molecular Weight
37,651 Da
NCBI Official Full Name
Complement factor H-related protein 1
NCBI Official Synonym Full Names
complement factor H related 1
NCBI Official Symbol
CFHR1 [Similar Products]
NCBI Official Synonym Symbols
CFHL; FHR1; HFL1; HFL2; CFHL1; H36-1; H36-2; CFHL1P; CFHR1P
[Similar Products]
NCBI Protein Information
complement factor H-related protein 1
UniProt Protein Name
Complement factor H-related protein 1
UniProt Synonym Protein Names
H factor-like protein 1; H-factor-like 1; H36
Protein Family
Complement factor H-related protein
UniProt Gene Name
CFHR1 [Similar Products]
UniProt Synonym Gene Names
CFHL; CFHL1; CFHL1P; CFHR1P; FHR1; HFL1; HFL2; FHR-1; H-factor-like 1 [Similar Products]
UniProt Entry Name
FHR1_HUMAN
NCBI Summary for CFHR1
This gene encodes a secreted protein belonging to the complement factor H protein family. It binds to Pseudomonas aeruginosa elongation factor Tuf together with plasminogen, which is proteolytically activated. It is proposed that Tuf acts as a virulence factor by acquiring host proteins to the pathogen surface, controlling complement, and facilitating tissue invasion. Mutations in this gene are associated with an increased risk of atypical hemolytic-uremic syndrome. [provided by RefSeq, Oct 2009]
UniProt Comments for CFHR1
CFHR1: Might be involved in complement regulation. Can associate with lipoproteins and may play a role in lipid metabolism.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 1q32
Cellular Component: extracellular space
Biological Process: complement activation
Disease: Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 1; Macular Degeneration, Age-related, 1
Research Articles on CFHR1
1. Next-generation sequencing of the CFH region identified putatively functional variants (missense, splice site and indel) on the four common haplotypes. We found no expression of any of the five CFH-related genes in the retina or RPE/Choroid/Sclera, in contrast to the liver, which is the main source of the circulating proteins. [CFHR1]
Precautions
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Disclaimer
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