CD104, Blocking Peptide

Integrin beta-4; GP150; CD104

For Research Use Only. Not for use in diagnostic procedures.

Synthetic

>85%

Lyophilized Powder

Shipped at 4 degree C. Store at -20 degree C for one year.

Small volumes of ITGB4 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

The peptide is used to block Anti-CD104 reactivity.

Blocking (BL)

Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.

106,779 Da

integrin subunit beta 4

integrin beta-4

Integrin beta-4

ITB4_HUMAN

Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

ITGB4: integrin alpha-6/beta-4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells. Five alternatively spliced isoforms have been described.

Protein type: Motility/polarity/chemotaxis; Receptor, misc.; Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 17q25

Cellular Component: basal plasma membrane; basement membrane; cell junction; cell surface; hemidesmosome; integrin complex; leading edge; nucleus; plasma membrane; receptor complex

Molecular Function: G-protein-coupled receptor binding; protein binding; receptor activity

Biological Process: autophagy; cell adhesion; cell motility involved in cell locomotion; cell-matrix adhesion; extracellular matrix organization and biogenesis; filopodium formation; gut development; hemidesmosome assembly; integrin-mediated signaling pathway; mesodermal cell differentiation; response to wounding; skin development

Disease: Epidermolysis Bullosa Junctionalis With Pyloric Atresia; Epidermolysis Bullosa Simplex, Localized; Epidermolysis Bullosa, Junctional, Non-herlitz Type

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