CFHR1, Polyclonal Antibody

CFHL; FHR1; HFL1; HFL2; CFHL1; H36-1; H36-2; CFHL1P; CFHR1P

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Antigen affinity purification

1mg/mL (lot specific)

Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

Manufactured in an ISO 9001:2015 Certified Laboratory.

Small volumes of anti-CFHR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This gene encodes a secreted protein belonging to the complement factor H protein family. It binds to Pseudomonas aeruginosa elongation factor Tuf together with plasminogen, which is proteolytically activated. It is proposed that Tuf acts as a virulence factor by acquiring host proteins to the pathogen surface, controlling complement, and facilitating tissue invasion. Mutations in this gene are associated with an increased risk of atypical hemolytic-uremic syndrome.

Western Blot (WB), Immunohistochemistry (IHC)

Western blot analysis of extracts of Mouse liver tissue, using CFHR1 antibody.

Immunohistochemistry of paraffin-embedded human liver cancer tissue using CFHR1antibody.

37,651 Da

complement factor H-related 1

complement factor H-related protein 1; FHR-1; H factor (complement)-like 1; H factor (complement)-like 2; H-factor-like 1; H36; complement factor H-related 1 pseudogene; h factor-like protein 1

Complement factor H-related protein 1

CFHL; CFHL1; CFHL1P; CFHR1P; FHR1; HFL1; HFL2; FHR-1; H-factor-like 1  [Similar Products]

FHR1_HUMAN

This gene encodes a secreted protein belonging to the complement factor H protein family. It binds to Pseudomonas aeruginosa elongation factor Tuf together with plasminogen, which is proteolytically activated. It is proposed that Tuf acts as a virulence factor by acquiring host proteins to the pathogen surface, controlling complement, and facilitating tissue invasion. Mutations in this gene are associated with an increased risk of atypical hemolytic-uremic syndrome. [provided by RefSeq, Oct 2009]

CFHR1: Might be involved in complement regulation. Can associate with lipoproteins and may play a role in lipid metabolism.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 1q32

Cellular Component: extracellular space

Biological Process: complement activation

Disease: Macular Degeneration, Age-related, 1; Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 1

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