Full Product Name
HADHA Antibody
Product Gene Name
anti-HADHA antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P40939
Other Notes
Small volumes of anti-HADHA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for HADHA. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000173.2
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NCBI GenBank Nucleotide #
NM_000182.4
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UniProt Primary Accession #
P40939
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UniProt Secondary Accession #
Q16679; Q53T69; Q53TA2; Q96GT7; Q9UQC5; B2R7L4; B4DYP2[Other Products]
UniProt Related Accession #
P40939[Other Products]
Molecular Weight
9,054 Da
NCBI Official Full Name
trifunctional enzyme subunit alpha, mitochondrial
NCBI Official Synonym Full Names
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha
NCBI Official Symbol
HADHA [Similar Products]
NCBI Official Synonym Symbols
GBP; ECHA; HADH; LCEH; MTPA; LCHAD; TP-ALPHA
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NCBI Protein Information
trifunctional enzyme subunit alpha, mitochondrial
UniProt Protein Name
Trifunctional enzyme subunit alpha, mitochondrial
UniProt Synonym Protein Names
78 kDa gastrin-binding protein; TP-alphaIncluding the following 2 domains:Long-chain enoyl-CoA hydratase (EC:4.2.1.17)Long chain 3-hydroxyacyl-CoA dehydrogenase (EC:1.1.1.211)
Protein Family
Trifunctional enzyme
UniProt Gene Name
HADHA [Similar Products]
UniProt Synonym Gene Names
HADH [Similar Products]
NCBI Summary for HADHA
This gene encodes the alpha subunit of the mitochondrial trifunctional protein, which catalyzes the last three steps of mitochondrial beta-oxidation of long chain fatty acids. The mitochondrial membrane-bound heterocomplex is composed of four alpha and four beta subunits, with the alpha subunit catalyzing the 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities. Mutations in this gene result in trifunctional protein deficiency or LCHAD deficiency. The genes of the alpha and beta subunits of the mitochondrial trifunctional protein are located adjacent to each other in the human genome in a head-to-head orientation. [provided by RefSeq, Jul 2008]
UniProt Comments for HADHA
Bifunctional subunit.
Research Articles on HADHA
1. C variant of HADHA gene in Kashubian population, suggesting the founder effect. For the first time we have found high frequency of rs71441018 in the South Poland Silesian population">study indicate described high frequency of c.1528G>C variant of HADHA gene in Kashubian population, suggesting the founder effect. For the first time we have found high frequency of rs71441018 in the South Poland Silesian population
Precautions
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Disclaimer
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