Product Name
Connexin-26 (GJB2), Polyclonal Antibody
Full Product Name
Connexin-26 Polyclonal Antibody
Product Gene Name
anti-GJB2 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P29033
Other Notes
Small volumes of anti-GJB2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for GJB2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_003995.2
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NCBI GenBank Nucleotide #
NM_004004.5
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UniProt Primary Accession #
P29033
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UniProt Secondary Accession #
Q508A5; Q508A6; Q5YLL0; Q5YLL1; Q5YLL4; Q6IPV5; Q86U88; Q96AK0; Q9H536; Q9NNY4[Other Products]
UniProt Related Accession #
P29033[Other Products]
Molecular Weight
26,215 Da[Similar Products]
NCBI Official Full Name
gap junction beta-2 protein
NCBI Official Synonym Full Names
gap junction protein beta 2
NCBI Official Symbol
GJB2 [Similar Products]
NCBI Official Synonym Symbols
HID; KID; PPK; CX26; DFNA3; DFNB1; NSRD1; DFNA3A; DFNB1A
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NCBI Protein Information
gap junction beta-2 protein
UniProt Protein Name
Gap junction beta-2 protein
UniProt Synonym Protein Names
Connexin-26; Cx26
Protein Family
Gap junction beta-2 protein
UniProt Gene Name
GJB2 [Similar Products]
UniProt Synonym Gene Names
Cx26 [Similar Products]
NCBI Summary for GJB2
This gene encodes a member of the gap junction protein family. The gap junctions were first characterized by electron microscopy as regionally specialized structures on plasma membranes of contacting adherent cells. These structures were shown to consist of cell-to-cell channels that facilitate the transfer of ions and small molecules between cells. The gap junction proteins, also known as connexins, purified from fractions of enriched gap junctions from different tissues differ. According to sequence similarities at the nucleotide and amino acid levels, the gap junction proteins are divided into two categories, alpha and beta. Mutations in this gene are responsible for as much as 50% of pre-lingual, recessive deafness. [provided by RefSeq, Oct 2008]
UniProt Comments for GJB2
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.CautionThe Thr-34 allele was originally thought to be a cause of autosomal dominant and recessive deafness (DFNA3 and DFNB1) (PubMed:9139825). However, Thr-34 effect on hearing is controversial. Some studies supports its pathogenic role (PubMed:17935238 and PubMed:16849369). Others provide evidence of the non-pathogenic nature of this variant (PubMed:9422505 and PubMed:14694360).
Research Articles on GJB2
1. A mutation allele of GJB2 was relatively lower in the profound Chinese nonsyndromic sensorineural hearing loss population in comparison to the moderate-to-profound ones, and the c.1174A>T mutation allele of SLC26A4 was relatively higher.">Compared with previous studies, we found that the c.109G>A mutation allele of GJB2 was relatively lower in the profound Chinese nonsyndromic sensorineural hearing loss population in comparison to the moderate-to-profound ones, and the c.1174A>T mutation allele of SLC26A4 was relatively higher.
Precautions
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