Product Name
Connexin-26 (Cx26), Polyclonal Antibody
Full Product Name
Connexin-26 Antibody
Product Synonym Names
Gap junction beta-2 protein; Connexin-26; GJB2
Product Gene Name
anti-Cx26 antibody
[Similar Products]
Product Synonym Gene Name
GJB2[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P29033
Species Reactivity
Human, Mouse, Rat
Specificity
Connexin-26 antibody detects endogenous levels of Connexin-26.
Purity/Purification
Purified from rabbit antiserum by affinity-chromatography using immunogen.
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1 mg/ml (lot specific)
Target Modification
Unmodified/Total
Immunogen
The antiserum was produced against synthesized peptide derived from human Connexin-26.
Preparation and Storage
Stable at -20 degree C for at least 1 year.
Other Notes
Small volumes of anti-Cx26 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-Cx26 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-Cx26 antibody
WB: 1:500~1:1000
ELISA: 1:10000
Western Blot (WB) of anti-Cx26 antibody
Western blot analysis of lysate from Jurkat cells, using Connexin-26 antibody.
NCBI/Uniprot data below describe general gene information for Cx26. It may not necessarily be applicable to this product.
NCBI Accession #
NP_003995.2
[Other Products]
NCBI GenBank Nucleotide #
NM_004004.5
[Other Products]
UniProt Primary Accession #
P29033
[Other Products]
UniProt Secondary Accession #
Q508A5; Q508A6; Q5YLL0; Q5YLL1; Q5YLL4; Q6IPV5; Q86U88; Q96AK0; Q9H536; Q9NNY4[Other Products]
UniProt Related Accession #
P29033[Other Products]
NCBI Official Full Name
gap junction beta-2 protein
NCBI Official Synonym Full Names
gap junction protein beta 2
NCBI Official Symbol
GJB2 [Similar Products]
NCBI Official Synonym Symbols
HID; KID; PPK; CX26; DFNA3; DFNB1; NSRD1; DFNA3A; DFNB1A
[Similar Products]
NCBI Protein Information
gap junction beta-2 protein
UniProt Protein Name
Gap junction beta-2 protein
UniProt Synonym Protein Names
Connexin-26; Cx26
UniProt Gene Name
GJB2 [Similar Products]
UniProt Synonym Gene Names
Cx26 [Similar Products]
NCBI Summary for Cx26
This gene encodes a member of the gap junction protein family. The gap junctions were first characterized by electron microscopy as regionally specialized structures on plasma membranes of contacting adherent cells. These structures were shown to consist of cell-to-cell channels that facilitate the transfer of ions and small molecules between cells. The gap junction proteins, also known as connexins, purified from fractions of enriched gap junctions from different tissues differ. According to sequence similarities at the nucleotide and amino acid levels, the gap junction proteins are divided into two categories, alpha and beta. Mutations in this gene are responsible for as much as 50% of pre-lingual, recessive deafness. [provided by RefSeq, Oct 2008]
UniProt Comments for Cx26
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Research Articles on Cx26
1. A was identified in three affected individuals (6%). The allelic frequency (14%) and low percentage of individuals that were homozygous (12%) and heterozygous (2%) for the c.35delG mutation suggest that there are other genes responsible for nonsyndromic deafness in the UAE population.">The homozygous mutation c.35delG was identified as the cause of hearing loss in six participants (12%). The mutation c.506G>A was identified in three affected individuals (6%). The allelic frequency (14%) and low percentage of individuals that were homozygous (12%) and heterozygous (2%) for the c.35delG mutation suggest that there are other genes responsible for nonsyndromic deafness in the UAE population.
Precautions
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Disclaimer
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