Full Product Name
GHRHR Rabbit Polyclonal
Product Gene Name
anti-GHRHR antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
>=95% as determined by SDS-PAGE
Immunogen Affinity Purified
Immunogen
Growth hormone releasing hormone receptor
Preparation and Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-GHRHR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-GHRHR antibody
ELISA (EIA), Western Blot (WB)
NCBI/Uniprot data below describe general gene information for GHRHR. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000814.2
[Other Products]
NCBI GenBank Nucleotide #
NM_000823.3
[Other Products]
UniProt Secondary Accession #
Q99863[Other Products]
UniProt Related Accession #
Q02643[Other Products]
Molecular Weight
47,402 Da
NCBI Official Full Name
growth hormone-releasing hormone receptor
NCBI Official Synonym Full Names
growth hormone releasing hormone receptor
NCBI Official Symbol
GHRHR [Similar Products]
NCBI Official Synonym Symbols
GRFR; GHRFR; IGHD1B
[Similar Products]
NCBI Protein Information
growth hormone-releasing hormone receptor
UniProt Protein Name
Growth hormone-releasing hormone receptor
UniProt Synonym Protein Names
Growth hormone-releasing factor receptor; GRF receptor; GRFR
Protein Family
Growth hormone-releasing hormone receptor
UniProt Gene Name
GHRHR [Similar Products]
UniProt Synonym Gene Names
GHRH receptor; GRF receptor; GRFR [Similar Products]
UniProt Entry Name
GHRHR_HUMAN
NCBI Summary for GHRHR
This gene encodes a receptor for growth hormone-releasing hormone. Binding of this hormone to the receptor leads to synthesis and release of growth hormone. Mutations in this gene have been associated with isolated growth hormone deficiency (IGHD), also known as Dwarfism of Sindh, a disorder characterized by short stature. [provided by RefSeq, Jun 2010]
UniProt Comments for GHRHR
GHRHR: Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion. Defects in GHRHR are a cause of growth hormone deficiency isolated type 1B (IGHD1B); also known as dwarfism of Sindh. IGHD1B is an autosomal recessive deficiency of GH which causes short stature. IGHD1B patients have low but detectable levels of GH. Belongs to the G-protein coupled receptor 2 family.
Protein type: Membrane protein, multi-pass; Cell development/differentiation; Membrane protein, integral; GPCR, family 2; Receptor, GPCR
Chromosomal Location of Human Ortholog: 7p14
Cellular Component: cell surface; cytoplasm; integral to membrane; nuclear inner membrane; nuclear matrix; nuclear outer membrane; plasma membrane; sarcolemma; secretory granule
Molecular Function: G-protein coupled receptor activity; growth factor binding; growth hormone-releasing hormone receptor activity; peptide hormone binding; protein binding
Biological Process: adenylate cyclase activation; cAMP-mediated signaling; cell maturation; cell surface receptor linked signal transduction; cellular response to insulin stimulus; determination of ***** life span; G-protein signaling, adenylate cyclase activating pathway; growth hormone secretion; hormone metabolic process; lactation; positive regulation of cAMP biosynthetic process; positive regulation of cell proliferation; positive regulation of circadian sleep/wake cycle, non-REM sleep; positive regulation of growth hormone secretion; positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of multicellular organism growth; regulation of protein metabolic process; regulation of steroid hormone receptor signaling pathway; reproductive process in a multicellular organism; response to estrogen stimulus; response to glucocorticoid stimulus; response to insulin stimulus; somatotropin secreting cell development; water homeostasis
Disease: Isolated Growth Hormone Deficiency, Type Ib
Research Articles on GHRHR
1. Identification of new missense mutations and an insertion mutation for the GHRHR gene in patients with isolated growth hormone deficiency.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
