Product Name
ATP6V1B1, Polyclonal Antibody
Full Product Name
ATP6V1B1 antibody - middle region
Product Gene Name
anti-ATP6V1B1 antibody
[Similar Products]
Product Synonym Gene Name
ATP6B1; MGC32642; RTA1B; VATB; VMA2; VPP3[Similar Products]
Antibody/Peptide Pairs
ATP6V1B1 peptide (MBS3237651) is used for blocking the activity of ATP6V1B1 antibody (MBS3212704)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
Synthetic peptide located within the following region: LMKSAIGEGM TRKDHGDVSN QLYACYAIGK DVQAMKAVVG EEALTSEDLL
3D Structure
ModBase 3D Structure for P11593
Species Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Yeast
Purity/Purification
Affinity Purified
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Homology
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 100%
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human ATP6V1B1
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-ATP6V1B1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ATP6V1B1 antibody
This is a rabbit polyclonal antibody against ATP6V1B1. It was validated on Western Blot using a cell lysate as a positive control.
Target Description: This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sort
Product Categories/Family for anti-ATP6V1B1 antibody
Polyclonal; Drugs and Drug Metabolism; Various;
Applications Tested/Suitable for anti-ATP6V1B1 antibody
Western Blot (WB)
Western Blot (WB) of anti-ATP6V1B1 antibody
Host: Mouse
Target Name: ATP6V1B2
Sample Tissue: Mouse Skeletal Muscle
Antibody Dilution: 1ug/ml

Western Blot (WB) of anti-ATP6V1B1 antibody
WB Suggested Anti-ATP6V1B1 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: Hela cell lysate

NCBI/Uniprot data below describe general gene information for ATP6V1B1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001683
[Other Products]
NCBI GenBank Nucleotide #
NM_001692
[Other Products]
UniProt Primary Accession #
P11593
[Other Products]
UniProt Related Accession #
P15313[Other Products]
NCBI Official Full Name
V-type proton ATPase subunit B, kidney isoform
NCBI Official Synonym Full Names
ATPase H+ transporting V1 subunit B1
NCBI Official Symbol
ATP6V1B1 [Similar Products]
NCBI Official Synonym Symbols
VATB; VMA2; VPP3; RTA1B; ATP6B1
[Similar Products]
NCBI Protein Information
V-type proton ATPase subunit B, kidney isoform
UniProt Protein Name
V-type proton ATPase subunit B
UniProt Synonym Protein Names
V-ATPase 57 kDa subunit; Vacuolar proton pump subunit B
Protein Family
V-type proton ATPase
UniProt Gene Name
vma-2 [Similar Products]
UniProt Synonym Gene Names
V-ATPase subunit B [Similar Products]
NCBI Summary for ATP6V1B1
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of two V1 domain B subunit isoforms and is found in the kidney. Mutations in this gene cause distal renal tubular acidosis associated with sensorineural deafness. [provided by RefSeq, Jul 2008]
UniProt Comments for ATP6V1B1
Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
Research Articles on ATP6V1B1
1. T, p.Pro137Ser; c.904C>T, p.Arg302Trp) were identified. In patient III 2 novel heterozygous duplications (c.1504dupT, p.Tyr502Leufs*22; c.2351dupT, p.Phe785Ilefs*28) were found.">In patient one, Two novel heterozygous missense mutations of the ATP6V1B1 gene (c.409C>T, p.Pro137Ser; c.904C>T, p.Arg302Trp) were identified. In patient III 2 novel heterozygous duplications (c.1504dupT, p.Tyr502Leufs*22; c.2351dupT, p.Phe785Ilefs*28) were found.
Precautions
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