Product Name
CLCNKB, cDNA Clone
Full Product Name
CLCNKB cDNA Clone
Product Gene Name
CLCNKB cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atggaggagt ttgtggggct gcgtgaaggc tcctcaggga accctgtgac tctgcaggag ctgtggggcc cctgtccccg catccgccga ggcatccgag gtggcctgga gtggctgaag cagaagctct tccgcctggg cgaggactgg tacttcctga tgaccctcgg ggtgctcatg gccctggtca gctgtgccat ggacttggct gttgagagtg tggtccgagc gcaccagtgg ctgtacaggg agattgggga cagccacctg ctccggtatc tctcctggac tgtgtaccct gtggccctcg tctctttctc ttcgggcttc tctcagagca tcacaccctc ctctggaggt tctggaatcc cggaggtgaa gaccatgttg gcgggtgtgg tcttggagga ctacctggat atcaagaact ttggggccaa agtggtgggc ctctcctgca ccctggcctg tggcagcacc ctcttcctcg gcaaagtggg ccctttcgtg cacctgtctg tgatgatggc tgcctacctg ggccgtgtgc gcaccacgac catcggggag cctgagaaca agagcaagcc tgtgtactcc gctctggcca ccttggttct cgcctccatc acctacccac ccagcgccgg ccgcttccta gcttctcggc tgtccatgaa gcagcatctg gactcgctgt tcgacaacca ctcctgggcg ctgatgaccc agaactccag cccaccctgg cccgaggagc tcgaccccca gcacctgtgg tgggaatggt accacccgcg gttcaccatc tttgggaccc ttgccttctt cctggttatg aagttctgga tgctgattct ggccaccacc atccccatgc ctgccgggta cttcatgccc atctttgtct atggagctgc tatcgggcgc ctctttgggg agactctctc ttttatcttc cctgagggca tcgtggctgg agggatcacc aatcccatca tgccaggggg gtatgctctg gcaggggctg cagccttctc aggggctgtg acccacacca tctccacggc gctgctggcc ttcgaggtga ccggccagat agtgcatgca ctgcccgtgc tgatggcggt gctggcagcc aacgccattg cacagagctg ccagccctcc ttctatgatg gcaccgtcat tgtcaagaag ctgccatacc tgccacggat tctgggccgc aacatcggtt cccaccgcgt gagggtggag cacttcatga accacagcat caccacactg gccatcacat taatgaatga tgagattgga gtacactgtc accaagggca ggcacagatg gcttctgggg ttgtctggtt cccagtgaga ggctcctga
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of CLCNKB cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for CLCNKB. It may not necessarily be applicable to this product.
NCBI Accession #
BC020873
[Other Products]
UniProt Secondary Accession #
Q5T5Q7; Q5T5Q8; B3KUY3[Other Products]
UniProt Related Accession #
P51801[Other Products]
Molecular Weight
56,998 Da
NCBI Official Full Name
Homo sapiens chloride channel Kb, mRNA
NCBI Official Synonym Full Names
chloride voltage-gated channel Kb
NCBI Official Symbol
CLCNKB [Similar Products]
NCBI Official Synonym Symbols
CLCKB; ClC-K2; ClC-Kb
[Similar Products]
NCBI Protein Information
chloride channel protein ClC-Kb
UniProt Protein Name
Chloride channel protein ClC-Kb
UniProt Synonym Protein Names
ClC-K2
Protein Family
Chloride channel protein
UniProt Gene Name
CLCNKB [Similar Products]
UniProt Synonym Gene Names
Chloride channel Kb [Similar Products]
UniProt Entry Name
CLCKB_HUMAN
NCBI Summary for CLCNKB
The protein encoded by this gene is a member of the family of voltage-gated chloride channels. Chloride channels have several functions, including the regulation of cell volume, membrane potential stabilization, signal transduction and transepithelial transport. This gene is expressed predominantly in the kidney and may be important for renal salt reabsorption. Mutations in this gene are associated with autosomal recessive Bartter syndrome type 3 (BS3). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
UniProt Comments for CLCNKB
CLCNKB: Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms. Defects in CLCNKB are the cause of Bartter syndrome type 3 (BS3); also known as classic Bartter syndrome. It is an autosomal recessive form of often severe intravascular volume depletion due to renal salt-wasting associated with low blood pressure, hypokalemic alkalosis, hypercalciuria, and normal serum magnesium levels. Defects in CLCNKB are a cause of Bartter syndrome type 4B (BS4B). A digenic, recessive disorder characterized by impaired salt reabsorption in the thick ascending loop of Henle with pronounced salt wasting, hypokalemic metabolic alkalosis, and varying degrees of hypercalciuria. Bartter syndrome type 4B is associated with sensorineural deafness. Belongs to the chloride channel (TC 2.A.49) family. CLCNKB subfamily.
Protein type: Transporter, ion channel; Membrane protein, integral; Membrane protein, multi-pass; Transporter
Chromosomal Location of Human Ortholog: 1p36
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: chloride ion binding; voltage-gated chloride channel activity
Biological Process: excretion; transport
Disease: Bartter Syndrome, Type 3; Bartter Syndrome, Type 4b
Research Articles on CLCNKB
1. Single loci of tag Single Nucleotide Polymorphisms of CLCNKA_B are not enough to increase the Essential Hypertension susceptibility, the combination of CLCNKA SNP, salt, marine products, meat, edible oil consumption is associated with elevated risk
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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