Full Product Name
ABCD3 Antibody
Product Gene Name
anti-ABCD3 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Purity/Purification
Affinity purified
Form/Format
PBS, pH 7.4 with 0.02% Sodium Azide
Concentration
1.0 mg/ml (lot specific)
Immunogen Type
Recombinant Protein
Immunogen Description
Recombinant protein
Preparation and Storage
This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Other Notes
Small volumes of anti-ABCD3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-ABCD3 antibody
Total protein Ab
Applications Tested/Suitable for anti-ABCD3 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Testing Data of anti-ABCD3 antibody
Testing Data of anti-ABCD3 antibody
NCBI/Uniprot data below describe general gene information for ABCD3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001116146.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001122674.1
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UniProt Secondary Accession #
Q15271; Q6NUN5; Q96DA3; Q9H529; D3DT46[Other Products]
UniProt Related Accession #
P28288[Other Products]
Molecular Weight
27,121 Da
NCBI Official Full Name
ATP-binding cassette sub-family D member 3 isoform b
NCBI Official Synonym Full Names
ATP-binding cassette, sub-family D (ALD), member 3
NCBI Official Symbol
ABCD3 [Similar Products]
NCBI Official Synonym Symbols
ZWS2; ABC43; CBAS5; PMP70; PXMP1
[Similar Products]
NCBI Protein Information
ATP-binding cassette sub-family D member 3
UniProt Protein Name
ATP-binding cassette sub-family D member 3
UniProt Synonym Protein Names
70 kDa peroxisomal membrane protein; PMP70
Protein Family
ABC transporter D family
UniProt Gene Name
ABCD3 [Similar Products]
UniProt Synonym Gene Names
PMP70; PXMP1; PMP70 [Similar Products]
UniProt Entry Name
ABCD3_HUMAN
NCBI Summary for ABCD3
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein likely plays an important role in peroxisome biogenesis. Mutations have been associated with some forms of Zellweger syndrome, a heterogeneous group of peroxisome assembly disorders. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
UniProt Comments for ABCD3
ABCD3: a member of the superfamily of ATP-binding cassette (ABC) transporters. Likely plays an important role in peroxisome biogenesis. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. Defects in ABCD3 may be the cause of Zellweger syndrome-2 (ZWS-2), an autosomal recessive disorder due to defective import mechanisms for peroxisomal matrix enzymes.
Protein type: Membrane protein, integral; Transporter, ABC family; Mitochondrial; Transporter; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 1p21.3
Cellular Component: peroxisomal membrane; peroxisomal matrix; membrane; intracellular membrane-bound organelle; mitochondrial inner membrane; integral to membrane; peroxisome; cytosol
Molecular Function: protein binding; protein homodimerization activity; ATPase activity, coupled to transmembrane movement of substances; ATPase activity; ATP binding
Biological Process: fatty acid beta-oxidation; very-long-chain fatty acid catabolic process; peroxisome organization and biogenesis; transmembrane transport
Disease: Bile Acid Synthesis Defect, Congenital, 5
Research Articles on ABCD3
1. We postulate a role for human ABCD3 in the oxidation of dicarboxylic acids and a role in buffering fatty acids that are overflowing from the mitochondrial beta-oxidation system
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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