EIF2B4, Polyclonal Antibody

Anti -EIF2B4, ID (K161) (EIF2B4, EIF2BD, Translation initiation factor eIF-2B subunit delta, eIF-2B GDP-GTP exchange factor subunit delta)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 2; NC_000002.11 (27587219..27593324, complement). Location: 2p23.3

Polyclonal

IgG

Rabbit

Human, mouse

Affinity Purified
Purified by Protein A affinity chromatography.

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Small volumes of anti-EIF2B4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Eukaryotic initiation factor 2B (EIF2B), which is necessary for protein synthesis, is a GTP exchange factor composed of five different subunits. The protein encoded by this gene is the fourth, or delta, subunit. Defects in this gene are a cause of leukoencephalopathy with vanishing white matter (VWM) and ovarioleukodystrophy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].

Antibodies; Abs to Translation Initiation Factors

ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)

Suitable for use in Western Blot, Immunohistochemistry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:50-100

57,557 Da[Similar Products]

eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa

translation initiation factor eIF-2B subunit delta; eIF-2B GDP-GTP exchange factor subunit delta; translation initiation factor eIF-2b delta subunit; eukaryotic translation initiation factor 2B subunit 4 delta

Translation initiation factor eIF-2B subunit delta

EIF2BD  [Similar Products]

EI2BD_HUMAN

Eukaryotic initiation factor 2B (EIF2B), which is necessary for protein synthesis, is a GTP exchange factor composed of five different subunits. The protein encoded by this gene is the fourth, or delta, subunit. Defects in this gene are a cause of leukoencephalopathy with vanishing white matter (VWM) and ovarioleukodystrophy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Function: Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.

Subunit structure: Complex of five different subunits; alpha, beta, gamma, delta and epsilon.

Involvement in disease: Leukodystrophy with vanishing white matter (VWM) [MIM:603896]: A leukodystrophy that occurs mainly in children. Neurological signs include progressive cerebellar ataxia, spasticity, inconstant optic atrophy and relatively preserved mental abilities. The disease is chronic-progressive with, in most individuals, additional episodes of rapid deterioration following febrile infections or minor head trauma. While childhood onset is the most common form of the disorder, some severe forms are apparent at birth. A severe, early-onset form seen among the Cree and Chippewayan populations of Quebec and Manitoba is called Cree leukoencephalopathy. Milder forms may not become evident until adolescence or *****hood. Some females with milder forms of the disease who survive to adolescence exhibit ovarian dysfunction. This variant of the disorder is called ovarioleukodystrophy.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.12 Ref.13 Ref.14

Sequence similarities: Belongs to the eIF-2B alpha/beta/delta subunits family.

Sequence caution: The sequence CAB57305.1 differs from that shown. Reason: Erroneous gene model prediction.

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