Product Name
EIF2B4, cDNA Clone
Full Product Name
EIF2B4 cDNA Clone
Product Gene Name
EIF2B4 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atggctgctg tggccgtggc tgttcgcgag gactcgggat ccgggatgaa ggcggagctt ccccctgggc ctggggcagt ggggagggaa atgaccaaag aagaaaagct gcagcttcgg aaggaaaaga aacagcagaa gaagaaacgg aaggaagaaa agggggcaga accagagact ggctctgctg tatctgcagc ccaatgtcaa gtaggcccaa ccagagaact gccagaatcg ggcattcagt tgggcactcc tcgggagaaa gttccagctg gtcggagtaa ggccgaactt cgggctgagc gtcgagccaa gcaggaggcc gagcgggccc tgaaacaggc aagaaaaggg gaacaaggag gaccacctcc taaggccagc cccagcacag ctggagaaac cccctcagga gtgaagcgtc tccctgagta ccctcaggtt gatgacctac ttctgagaag gcttgttaaa aaaccagagc gtcaacaggt tcctacacga aaggattatg gatccaaagt cagtctcttc tctcacctac cccagtacag cagacaaaac tctctgaccc agtttatgag catcccatcc tctgtgatcc acccagccat ggtgcgactc ggcctgcagt actcccaggg cctggtcagt ggctccaatg cccggtgtat tgccctgctt cgtgccttgc agcaggtgat tcaggattac acaacaccgc ctaatgaaga actctccagg gatctagtga ataaactaaa accctacatg agcttcctga ctcagtgccg tcccctgtca gcgagcatgc acaacgccat caagttcctt aacaaggaaa tcaccagtgt gggcagttcc aagcgggaag aggaggccaa gtcagaactt cgagcagcca ttgatcggta tgtgcaagag aagattgtgc tagcagctca ggcaatttca cgctttgctt accagaagat cagtaatgga gatgtgatcc tggtatatgg atgctcatct ctggtatcac gaattcttca ggaggcttgg acagagggcc ggcggtttcg ggtggtagtg gtggacagcc ggccatggct ggaaggaagg cacacactac gttctctagt ccatgctggt gtcccagcct cctacctgct gattcctgca gcctcctatg tgctcccaga ggtttccaag gtgctattgg gagctcatgc actcttggcc aacgggtctg tgatgtcacg ggtagggaca gcacagttag ccctggtggc tcgagcccat aatgtaccag tgctggtttg ctgtgaaaca tacaagttct gtgagcgtgt gcagactgat gcctttgtct ctaatgagct agatgaccct gatgatctgc aatgtaagcg gggagaacat gttgcgctgg ctaactggca gaaccacgca tccctacggt tgttgaatct agtctatgat gtgactcccc cagagcttgt ggatctggtg atcacggagc tggggatgat cccttgcagt tctgtacctg ttgttctacg agtcaagagc agtgaccagt ga
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of EIF2B4 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for EIF2B4. It may not necessarily be applicable to this product.
NCBI Accession #
BC001870
[Other Products]
UniProt Secondary Accession #
Q53RY7; Q5BJF4; Q9BUV9; Q9UBG4; Q9UIQ9; Q9UJ95[Other Products]
UniProt Related Accession #
Q9UI10[Other Products]
Molecular Weight
57,458 Da
NCBI Official Full Name
Homo sapiens eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa, mRNA
NCBI Official Synonym Full Names
eukaryotic translation initiation factor 2B subunit delta
NCBI Official Symbol
EIF2B4 [Similar Products]
NCBI Official Synonym Symbols
EIF2B; EIF-2B; EIF2Bdelta
[Similar Products]
NCBI Protein Information
translation initiation factor eIF-2B subunit delta
UniProt Protein Name
Translation initiation factor eIF-2B subunit delta
UniProt Synonym Protein Names
eIF-2B GDP-GTP exchange factor subunit delta
Protein Family
Translation initiation factor
UniProt Gene Name
EIF2B4 [Similar Products]
UniProt Synonym Gene Names
EIF2BD [Similar Products]
UniProt Entry Name
EI2BD_HUMAN
NCBI Summary for EIF2B4
Eukaryotic initiation factor 2B (EIF2B), which is necessary for protein synthesis, is a GTP exchange factor composed of five different subunits. The protein encoded by this gene is the fourth, or delta, subunit. Defects in this gene are a cause of leukoencephalopathy with vanishing white matter (VWM) and ovarioleukodystrophy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for EIF2B4
eIF2B-delta: Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. Defects in EIF2B4 are a cause of leukodystrophy with vanishing white matter (VWM). VWM is a leukodystrophy that occurs mainly in children. Neurological signs include progressive cerebellar ataxia, spasticity, inconstant optic atrophy and relatively preserved mental abilities. The disease is chronic-progressive with, in most individuals, additional episodes of rapid deterioration following febrile infections or minor head trauma. While childhood onset is the most common form of the disorder, some severe forms are apparent at birth. A severe, early-onset form seen among the Cree and Chippewayan populations of Quebec and Manitoba is called Cree leukoencephalopathy. Milder forms may not become evident until adolescence or *****hood. Some females with milder forms of the disease who survive to adolescence exhibit ovarian dysfunction. This variant of the disorder is called ovarioleukodystrophy. Belongs to the eIF-2B alpha/beta/delta subunits family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Translation initiation; Translation
Chromosomal Location of Human Ortholog: 2p23.3
Cellular Component: cytoplasm; cytosol; eukaryotic translation initiation factor 2B complex
Molecular Function: guanyl-nucleotide exchange factor activity; protein binding; S-methyl-5-thioribose-1-phosphate isomerase activity; translation initiation factor activity; translation initiation factor binding
Biological Process: cellular response to stimulus; methionine salvage; myelination; negative regulation of translation initiation in response to stress; negative regulation of translational initiation; oligodendrocyte development; ovarian follicle development; response to glucose stimulus; response to heat; response to peptide hormone stimulus; translational initiation
Disease: Leukoencephalopathy With Vanishing White Matter
Research Articles on EIF2B4
1. A novel missense mutation within EIF2B4 is associated with vanishing white matter disease.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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