eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa, ELISA Kit

Human Translation initiation factor eIF-2B subunit alpha (EIF2B1) ELISA kit; EIF2B; EIF2BA; MGC117409; MGC125868; MGC125869; eIF-2B GDP-GTP exchange factor subunit alpha; eukaryotic translation initiation factor 2B; subunit 1 alpha; 26kDa

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of EIF2B1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9318742 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa (EIF2B1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing EIF2B1. The ELISA analytical biochemical technique of the MBS9318742 kit is based on EIF2B1 antibody-EIF2B1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect EIF2B1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, EIF2B1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

33,712 Da

eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa

translation initiation factor eIF-2B subunit alpha; eIF-2B GDP-GTP exchange factor subunit alpha

Translation initiation factor eIF-2B subunit alpha

EIF2BA  [Similar Products]

EI2BA_HUMAN

This gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter. [provided by RefSeq, Oct 2009]

eIF2B-alpha: Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. Defects in EIF2B1 are a cause of leukodystrophy with vanishing white matter (VWM). VWM is a leukodystrophy that occurs mainly in children. Neurological signs include progressive cerebellar ataxia, spasticity, inconstant optic atrophy and relatively preserved mental abilities. The disease is chronic-progressive with, in most individuals, additional episodes of rapid deterioration following febrile infections or minor head trauma. While childhood onset is the most common form of the disorder, some severe forms are apparent at birth. A severe, early-onset form seen among the Cree and Chippewayan populations of Quebec and Manitoba is called Cree leukoencephalopathy. Milder forms may not become evident until adolescence or *****hood. Some females with milder forms of the disease who survive to adolescence exhibit ovarian dysfunction. This variant of the disorder is called ovarioleukodystrophy. Belongs to the eIF-2B alpha/beta/delta subunits family.

Protein type: Translation; Translation initiation

Chromosomal Location of Human Ortholog: 12q24.31

Cellular Component: eukaryotic translation initiation factor 2B complex; membrane; cytoplasm; plasma membrane; cytosol

Molecular Function: protein binding; GDP binding; GTP binding; translation initiation factor activity; guanyl-nucleotide exchange factor activity; S-methyl-5-thioribose-1-phosphate isomerase activity; enzyme regulator activity

Biological Process: response to peptide hormone stimulus; cellular protein metabolic process; translation; methionine salvage; response to heat; response to glucose stimulus; translational initiation; negative regulation of translation initiation in response to stress; cellular response to stimulus; gene expression; oligodendrocyte development; regulation of translational initiation; positive regulation of GTPase activity

Disease: Leukoencephalopathy With Vanishing White Matter

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