Product Name
Glucose-6-phosphatase (G6pc), Recombinant Protein
Full Product Name
Recombinant Mouse Glucose-6-phosphatase (G6pc)
Product Gene Name
G6pc recombinant protein
[Similar Products]
Product Synonym Gene Name
Recombinant Glucose-6-phosphatase (G6pc); Glucose-6-phosphatase; G-6-Pase; G6Pase EC= 3.1.3.9[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-28. Fragment at the N-terminal, provide a fragment of the complete Lumenal domain
Sequence
MEEGMNILHD FGIQSTRYLQ VNYQDSQD
Chromosome Location
Chromosome: 11; NC_000077.6 (101367730..101377903). Location: 11 D; 11
3D Structure
ModBase 3D Structure for P35576
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>=90% (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Mus musculus (Mouse)
Preparation and Storage
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of G6pc recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
G6pc recombinant protein
G6pc; G6pt
NCBI/Uniprot data below describe general gene information for G6pc. It may not necessarily be applicable to this product.
NCBI Accession #
NP_032087.2
[Other Products]
NCBI GenBank Nucleotide #
NM_008061.3
[Other Products]
UniProt Primary Accession #
P35576
[Other Products]
UniProt Secondary Accession #
Q91WV3[Other Products]
UniProt Related Accession #
P35576[Other Products]
Molecular Weight
40,473 Da[Similar Products]
NCBI Official Full Name
glucose-6-phosphatase
NCBI Official Synonym Full Names
glucose-6-phosphatase, catalytic
NCBI Official Symbol
G6pc [Similar Products]
NCBI Official Synonym Symbols
G6pt; G6Pase; AW107337; Glc-6-Pase
[Similar Products]
NCBI Protein Information
glucose-6-phosphatase; G-6-Pase; Glc-6-Pase-alpha
UniProt Protein Name
Glucose-6-phosphatase
Protein Family
Glucose-6-phosphatase
UniProt Gene Name
G6pc [Similar Products]
UniProt Synonym Gene Names
G6pt; G-6-Pase; G6Pase [Similar Products]
UniProt Entry Name
G6PC_MOUSE
UniProt Comments for G6pc
G6PC: Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels. Defects in G6PC are the cause of glycogen storage disease type 1A (GSD1A). A metabolic disorder characterized by impairment of terminal steps of glycogenolysis and gluconeogenesis. Patients manifest a wide range of clinical symptoms and biochemical abnormalities, including hypoglycemia, severe hepatomegaly due to excessive accumulation of glycogen, kidney enlargement, growth retardation, lactic acidemia, hyperlipidemia, and hyperuricemia. Belongs to the glucose-6-phosphatase family.
Protein type: EC 3.1.3.9; Carbohydrate Metabolism - galactose; Membrane protein, integral; Transporter, SLC family; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Transporter; Membrane protein, multi-pass; Carbohydrate Metabolism - starch and sucrose; Phosphatase (non-protein); Endoplasmic reticulum
Cellular Component: intracellular membrane-bound organelle; membrane; endoplasmic reticulum; integral to membrane; integral to endoplasmic reticulum membrane
Molecular Function: hydrolase activity; glucose-6-phosphatase activity; phosphate binding; phosphotransferase activity, alcohol group as acceptor; catalytic activity
Biological Process: glycogen metabolic process; steroid metabolic process; phosphorylated carbohydrate dephosphorylation; glycogen catabolic process; multicellular organism growth; glucose 6-phosphate metabolic process; lipid homeostasis; glucose homeostasis; phosphate metabolic process; gluconeogenesis; cholesterol homeostasis; urate metabolic process; triacylglycerol metabolic process; dephosphorylation; regulation of gene expression; glucose-6-phosphate transport
Research Articles on G6pc
1. We conclude that G6PD deficiency at the level of the animals in the present study may not be a risk factor for developing CSN-OT, but this remains to be verified for human subjects
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
