Product Name
MAOA, Blocking Peptide
Full Product Name
MAOA Blocking Peptide (C-term)
Product Synonym Names
Amine oxidase [flavin-containing] A; Monoamine oxidase type A; MAO-A; MAOA
Product Gene Name
MAOA blocking peptide
[Similar Products]
MAOA peptide (MBS9229704) is used for blocking the activity of MAOA antibody (MBS9200867)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P21397
Specificity
The synthetic peptide sequence is selected from aa 465-479 of HUMAN MAOA
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Cellular Location
Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side
Tissue Location
Heart, liver, duodenum, blood vessels and kidney
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Other Notes
Small volumes of MAOA blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
MAOA blocking peptide
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.
NCBI/Uniprot data below describe general gene information for MAOA. It may not necessarily be applicable to this product.
NCBI Accession #
P21397.1
[Other Products]
UniProt Primary Accession #
P21397
[Other Products]
UniProt Secondary Accession #
Q16426; B4DF46[Other Products]
UniProt Related Accession #
P21397[Other Products]
Molecular Weight
44,848 Da
NCBI Official Full Name
Amine oxidase
NCBI Official Synonym Full Names
monoamine oxidase A
NCBI Official Symbol
MAOA [Similar Products]
NCBI Official Synonym Symbols
MAO-A
[Similar Products]
NCBI Protein Information
amine oxidase [flavin-containing] A
UniProt Protein Name
Amine oxidase [flavin-containing] A
UniProt Synonym Protein Names
Monoamine oxidase type A; MAO-A
Protein Family
Amine oxidase
UniProt Gene Name
MAOA [Similar Products]
UniProt Synonym Gene Names
MAO-A [Similar Products]
UniProt Entry Name
AOFA_HUMAN
NCBI Summary for MAOA
This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin. Mutation of this gene results in Brunner syndrome. This gene has also been associated with a variety of other psychiatric disorders, including antisocial behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]
UniProt Comments for MAOA
MAOA: Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine. Defects in MAOA are the cause of Brunner syndrome (BRUNS). Brunner syndrome is a form of X-linked non- dysmorphic mild mental retardation. Male patients are affected by a syndrome of borderline mental retardation and exhibit abnormal behavior, including disturbed regulation of impulsive aggression. Obligate female carriers have normal intelligence and behavior. Belongs to the flavin monoamine oxidase family.
Protein type: Amino Acid Metabolism - histidine; EC 1.4.3.4; Amino Acid Metabolism - tyrosine; Membrane protein, integral; Amino Acid Metabolism - glycine, serine and threonine; Oxidoreductase; Amino Acid Metabolism - arginine and proline; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - phenylalanine
Chromosomal Location of Human Ortholog: Xp11.3
Cellular Component: mitochondrial outer membrane; mitochondrion
Molecular Function: amine oxidase activity
Biological Process: biogenic amine metabolic process; dopamine catabolic process; neurotransmitter metabolic process
Disease: Brunner Syndrome
Research Articles on MAOA
1. Study demonstrated lower brain MAO-A levels in antisocial personality disorder, support an important extension of preclinical models of impulsive aggression into a human disorder marked by pathological aggression and impulsivity
Precautions
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Disclaimer
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