Product Name
COL25A1, Polyclonal Antibody
Full Product Name
COL25A1 Polyclonal Antibody
Product Gene Name
anti-COL25A1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9BXS0
Other Notes
Small volumes of anti-COL25A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for COL25A1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_115907.2
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NCBI GenBank Nucleotide #
NM_032518.2
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UniProt Primary Accession #
Q9BXS0
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UniProt Secondary Accession #
Q9BXR9; A8MPZ6[Other Products]
UniProt Related Accession #
Q9BXS0[Other Products]
Molecular Weight
57,619 Da
NCBI Official Full Name
collagen alpha-1(XXV) chain isoform 2
NCBI Official Synonym Full Names
collagen type XXV alpha 1 chain
NCBI Official Symbol
COL25A1 [Similar Products]
NCBI Official Synonym Symbols
AMY; CLAC; CLACP; CFEOM5; CLAC-P
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NCBI Protein Information
collagen alpha-1(XXV) chain
UniProt Protein Name
Collagen alpha-1(XXV) chain
UniProt Synonym Protein Names
Alzheimer disease amyloid-associated protein; AMY
UniProt Gene Name
COL25A1 [Similar Products]
UniProt Synonym Gene Names
AMY; CLAC [Similar Products]
NCBI Summary for COL25A1
This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
UniProt Comments for COL25A1
Inhibits fibrillization of amyloid-beta peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin.
Research Articles on COL25A1
1. We highlight phenotypes of the 4 affected children from the 2 reported families: isolated congenital ptosis (one unilateral, one bilateral) and Duane syndrome (one unilateral, one bilateral) with synergistic divergence.
Precautions
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Disclaimer
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