Product Name
Cytokeratin 14 (CK-14), Polyclonal Antibody
Full Product Name
Cytokeratin 14 Polyclonal Antibody
Product Gene Name
anti-CK-14 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P02533
Other Notes
Small volumes of anti-CK-14 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for CK-14. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000517.2
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NCBI GenBank Nucleotide #
NM_000526.4
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UniProt Primary Accession #
P02533
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UniProt Secondary Accession #
Q14715; Q53XY3; Q9BUE3; Q9UBN2; Q9UBN3; Q9UCY4[Other Products]
UniProt Related Accession #
P02533[Other Products]
Molecular Weight
51,561 Da
NCBI Official Full Name
keratin, type I cytoskeletal 14
NCBI Official Synonym Full Names
keratin 14
NCBI Official Symbol
KRT14 [Similar Products]
NCBI Official Synonym Symbols
K14; NFJ; CK14; EBS3; EBS4
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NCBI Protein Information
keratin, type I cytoskeletal 14
UniProt Protein Name
Keratin, type I cytoskeletal 14
UniProt Synonym Protein Names
Cytokeratin-14; CK-14; Keratin-14; K14
UniProt Gene Name
KRT14 [Similar Products]
UniProt Synonym Gene Names
CK-14; K14 [Similar Products]
NCBI Summary for CK-14
This gene encodes a member of the keratin family, the most diverse group of intermediate filaments. This gene product, a type I keratin, is usually found as a heterotetramer with two keratin 5 molecules, a type II keratin. Together they form the cytoskeleton of epithelial cells. Mutations in the genes for these keratins are associated with epidermolysis bullosa simplex. At least one pseudogene has been identified at 17p12-p11. [provided by RefSeq, Jul 2008]
UniProt Comments for CK-14
The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro.
Research Articles on CK-14
1. the findings show that squamous and micropapillary bladder cancers have different expression patterns of CK14 and FOXA1 and suggest that they arise from distinct precursors.
Precautions
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Disclaimer
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