Product Name
Collagen XXV (COL25A1), Antibody
Full Product Name
Collagen XXV Antibody
Product Synonym Names
Collagen alpha-1(XXV) chain; CLAC-P; Alzheimer disease amyloid-associated protein; AMY; Collagen-like Alzheimer amyloid plaque component; COPA1
Product Gene Name
anti-COL25A1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9BXS0
Species Reactivity
Human, Mouse
Specificity
Collagen XXV antibody detects endogenous levels of total Collagen XXV protein.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
The antiserum was produced against synthesized peptide derived from internal of human Collagen XXV.
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-COL25A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-COL25A1 antibody
Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
Applications Tested/Suitable for anti-COL25A1 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-COL25A1 antibody
WB: 1:500~1:1000
ELISA: 1:20000
Western Blot (WB) of anti-COL25A1 antibody
Western blot analysis of extracts from Jurkat cells and A549 cells, using Collagen XXV antibody.
NCBI/Uniprot data below describe general gene information for COL25A1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_115907.2
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NCBI GenBank Nucleotide #
NM_032518.2
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UniProt Primary Accession #
Q9BXS0
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UniProt Secondary Accession #
Q9BXR9; A8MPZ6[Other Products]
UniProt Related Accession #
Q9BXS0[Other Products]
Molecular Weight
57,619 Da[Similar Products]
NCBI Official Full Name
collagen alpha-1(XXV) chain isoform 2
NCBI Official Synonym Full Names
collagen type XXV alpha 1 chain
NCBI Official Symbol
COL25A1 [Similar Products]
NCBI Official Synonym Symbols
AMY; CLAC; CLACP; CFEOM5; CLAC-P
[Similar Products]
NCBI Protein Information
collagen alpha-1(XXV) chain
UniProt Protein Name
Collagen alpha-1(XXV) chain
UniProt Synonym Protein Names
Alzheimer disease amyloid-associated protein; AMY
UniProt Gene Name
COL25A1 [Similar Products]
UniProt Synonym Gene Names
AMY; CLAC [Similar Products]
NCBI Summary for COL25A1
This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
UniProt Comments for COL25A1
Inhibits fibrillization of amyloid-beta peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin.
Product References and Citations for anti-COL25A1 antibody
Hashimoto T., EMBO J. 21:1524-1534(2002). Soederberg L., J. Neuropathol. Exp. Neurol. 62:1108-1117(2003). Soederberg L., J. Biol. Chem. 280:1007-1015(2005).
Research Articles on COL25A1
1. We highlight phenotypes of the 4 affected children from the 2 reported families: isolated congenital ptosis (one unilateral, one bilateral) and Duane syndrome (one unilateral, one bilateral) with synergistic divergence.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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