Full Product Name
ATP7A Antibody
Product Synonym Names
MK; MNK; DSMAX; SMAX3
Product Gene Name
anti-ATP7A antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q04656
Specificity
The antibody detects endogenous levels of total ATP7A protein.
Purity/Purification
Antigen affinity purification.
Form/Format
Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Concentration
4 mg/ml (lot specific)
Immunogen Description
Synthetic peptide corresponding to residues near the C terminal of human ATPase, Cu++ transporting, alpha polypeptide
Preparation and Storage
Store at -20 degree C
Other Notes
Small volumes of anti-ATP7A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ATP7A antibody
This gene encodes a transmembrane protein that functions in copper transport across membranes. This protein is localized to the trans Golgi network, where it is predicted to supply copper to copper-dependent enzymes in the secretory pathway. It relocalizes to the plasma membrane under conditions of elevated extracellular copper, and functions in the efflux of copper from cells. Mutations in this gene are associated with Menkes disease, X-linked distal spinal muscular atrophy, and occipital horn syndrome. Alternatively-spliced transcript variants have been observed.
Product Categories/Family for anti-ATP7A antibody
Total protein Ab
Applications Tested/Suitable for anti-ATP7A antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-ATP7A antibody
Western blotting: 1:200-1:1000
Immunohistochemistry: 1:50-1:200
Testing Data of anti-ATP7A antibody
Gel: 6%SDS-PAGE Lysate: 40ug HepG2 cell Primary antibody: 1/800 dilution Secondary antibody dilution: 1/8000 Exposure time: 10 minutes
Immunohistochemistry (IHC) of anti-ATP7A antibody
Immunohistochemical analysis of paraffin-embedded Human gastric cancer tissue using at dilution 1/50.
NCBI/Uniprot data below describe general gene information for ATP7A. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000043.4
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NCBI GenBank Nucleotide #
NM_000052.6
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UniProt Primary Accession #
Q04656
[Other Products]
UniProt Secondary Accession #
O00227; O00745; Q9BYY8; B1AT72[Other Products]
UniProt Related Accession #
Q04656[Other Products]
Molecular Weight
11,522 Da
NCBI Official Full Name
copper-transporting ATPase 1 isoform 1
NCBI Official Synonym Full Names
ATPase, Cu++ transporting, alpha polypeptide
NCBI Official Symbol
ATP7A [Similar Products]
NCBI Official Synonym Symbols
MK; MNK; DSMAX; SMAX3
[Similar Products]
NCBI Protein Information
copper-transporting ATPase 1
UniProt Protein Name
Copper-transporting ATPase 1
UniProt Synonym Protein Names
Copper pump 1; Menkes disease-associated protein
UniProt Gene Name
ATP7A [Similar Products]
UniProt Synonym Gene Names
MC1; MNK [Similar Products]
UniProt Entry Name
ATP7A_HUMAN
NCBI Summary for ATP7A
This gene encodes a transmembrane protein that functions in copper transport across membranes. This protein is localized to the trans Golgi network, where it is predicted to supply copper to copper-dependent enzymes in the secretory pathway. It relocalizes to the plasma membrane under conditions of elevated extracellular copper, and functions in the efflux of copper from cells. Mutations in this gene are associated with Menkes disease, X-linked distal spinal muscular atrophy, and occipital horn syndrome. Alternatively-spliced transcript variants have been observed. [provided by RefSeq, Aug 2013]
UniProt Comments for ATP7A
May supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-Golgi network. Under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells.
Research Articles on ATP7A
1. This study demonstrated that G727R missense mutation may be relatively common in Korea.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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