calcium channel, voltage-dependent, beta 4 subunit, ELISA Kit

Mouse Voltage-dependent L-type calcium channel subunit beta-4 (CACNB4) ELISA kit; CAB4; CACNLB4; EA5; EIG9; EJM; EJM4; EJM6; OTTHUMP00000207247; OTTHUMP00000207249; dihydropyridine-sensitive L-type; calcium channel beta-4 subunit; calcium channel; voltage-dependent; beta 4 subunit

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.

Small volumes of CACNB4 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9319757 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the calcium channel, voltage-dependent, beta 4 subunit (CACNB4) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing CACNB4. The ELISA analytical biochemical technique of the MBS9319757 kit is based on CACNB4 antibody-CACNB4 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect CACNB4 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, CACNB4. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

57,950 Da

calcium channel, voltage-dependent, beta 4 subunit

voltage-dependent L-type calcium channel subunit beta-4; CAB4; calcium channel voltage-dependent subunit beta 4

Voltage-dependent L-type calcium channel subunit beta-4

Cacnlb4; CAB4  [Similar Products]

CACB4_MOUSE

CACNB4: The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting. Defects in CACNB4 are the cause of susceptibility to epilepsy, idiopathic generalized type 9 (EIG9). A disorder characterized by recurring generalized seizures in the absence of detectable brain lesions and/or metabolic abnormalities. Generalized seizures arise diffusely and simultaneously from both hemispheres of the brain. Defects in CACNB4 are the cause of susceptibility to juvenile myoclonic epilepsy type 6 (EJM6). EJM6 is a subtype of idiopathic generalized epilepsy. Patients have afebrile seizures only, with onset in adolescence (rather than in childhood) and myoclonic jerks which usually occur after awakening and are triggered by sleep deprivation and fatigue. Defects in CACNB4 are the cause of episodic ataxia type 5 (EA5). EA5 is a disorder characterized by episodes of vertigo and ataxia that last for several hours. Interictal examination show spontaneous downbeat and gaze-evoked nystagmus, mild dysarthria and truncal ataxia. Belongs to the calcium channel beta subunit family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, calcium

Cellular Component: plasma membrane; voltage-gated calcium channel complex; synapse

Molecular Function: voltage-gated calcium channel activity; protein binding; calcium channel activity; high voltage-gated calcium channel activity; voltage-gated ion channel activity; protein kinase binding

Biological Process: spleen development; Peyer's patch development; synaptic transmission, glutamatergic; thymus development; gamma-aminobutyric acid secretion; synaptic transmission, GABAergic; T cell receptor signaling pathway; ***** walking behavior; neurological system process; cellular calcium ion homeostasis; regulation of membrane potential; cAMP metabolic process; transport; calcium ion transport; action potential propagation; detection of light stimulus involved in visual perception; ion transport; muscle fiber development; gamma-aminobutyric acid signaling pathway; neuromuscular junction development; T cell differentiation

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.