Full Product Name
CDKL5 Antibody
Product Synonym Names
CDKL5; Cyclin-dependent kinase-like 5; ISSX; Serine/threonine kinase 9; STK9; EIEE2
Product Gene Name
anti-CDKL5 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O76039
Species Reactivity
Human, Mouse
Specificity
CDKL5 Antibody detects endogenous levels of total CDKL5
Form/Format
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1.0mg/mL (lot specific)
Immunogen
A synthesized peptide derived from human CDKL5
Preparation and Storage
Store at -20 degree C
Other Notes
Small volumes of anti-CDKL5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-CDKL5 antibody
Total protein Ab
Applications Tested/Suitable for anti-CDKL5 antibody
Western Blot (WB)
Application Notes for anti-CDKL5 antibody
Western Blot: 1:1000-3000
Western Blot (WB) of anti-CDKL5 antibody
Western blot analysis CDKL5 using K562 whole cell lysates
NCBI/Uniprot data below describe general gene information for CDKL5. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001032420.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001037343.1
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UniProt Primary Accession #
O76039
[Other Products]
UniProt Secondary Accession #
Q14198; Q5H985; Q8IYC7; Q9UJL6; G9B9X4[Other Products]
UniProt Related Accession #
O76039[Other Products]
Molecular Weight
107,519 Da
NCBI Official Full Name
cyclin-dependent kinase-like 5 isoform 1
NCBI Official Synonym Full Names
cyclin dependent kinase like 5
NCBI Official Symbol
CDKL5 [Similar Products]
NCBI Official Synonym Symbols
ISSX; STK9; EIEE2; CFAP247
[Similar Products]
NCBI Protein Information
cyclin-dependent kinase-like 5
UniProt Protein Name
Cyclin-dependent kinase-like 5
UniProt Synonym Protein Names
Serine/threonine-protein kinase 9
Protein Family
Cyclin-dependent kinase
UniProt Gene Name
CDKL5 [Similar Products]
UniProt Synonym Gene Names
STK9 [Similar Products]
UniProt Entry Name
CDKL5_HUMAN
NCBI Summary for CDKL5
This gene is a member of Ser/Thr protein kinase family and encodes a phosphorylated protein with protein kinase activity. Mutations in this gene have been associated with X-linked infantile spasm syndrome (ISSX), also known as X-linked West syndrome, and Rett syndrome (RTT). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
UniProt Comments for CDKL5
CDKL5: a protein kinase of the CDKL family. Mutations have been associated with X-linked infantile spasm syndrome (ISSX), also known as X-linked West syndrome, and Rett syndrome (RTT). Alternate transcriptional splice variants have been characterized.
Protein type: CDKL family; CMGC group; Cell cycle regulation; EC 2.7.11.22; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: Xp22
Cellular Component: cytoplasm; dendrite cytoplasm; nucleoplasm; nucleus
Molecular Function: ATP binding; kinase activity; protein kinase activity; protein serine/threonine kinase activity; Rac GTPase binding
Biological Process: neuron migration; positive regulation of axon extension; positive regulation of dendrite morphogenesis; positive regulation of GTPase activity; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of dendrite development
Disease: Epileptic Encephalopathy, Early Infantile, 2
Research Articles on CDKL5
1. Rett syndrome with early epilepsy and the congenital variant are mainly due to variations in the CDKL5 and FOXG1 genes, respectively
Precautions
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Disclaimer
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