SLC12A6, Polyclonal Antibody

KCC3; ACCPN; KCC3A; KCC3B

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

The antibody detects endogenous levels of total SLC12A6 protein.

Antigen affinity purification.

Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.

1.2 mg/ml (lot specific)

Store at -20 degree C

Small volumes of anti-SLC12A6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This gene is a member of the K-Cl cotransporter (KCC) family. K-Cl cotransporters are integral membrane proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The proteins encoded by this gene are activated by cell swelling induced by hypotonic conditions. Alternate splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are associated with agenesis of the corpus callosum with peripheral neuropathy.

Total protein Ab

Immunohistochemistry (IHC)

Immunohistochemistry: 1:50-1:200

Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue using at dilution 1/40.

Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue using at dilution 1/40.

120,467 Da

solute carrier family 12 (potassium/chloride transporter), member 6

solute carrier family 12 member 6

Solute carrier family 12 member 6

KCC3  [Similar Products]

S12A6_HUMAN

This gene is a member of the K-Cl cotransporter (KCC) family. K-Cl cotransporters are integral membrane proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The proteins encoded by this gene are activated by cell swelling induced by hypotonic conditions. Alternate splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are associated with agenesis of the corpus callosum with peripheral neuropathy. [provided by RefSeq, Jul 2008]

KCC3: Mediates electroneutral potassium-chloride cotransport. May be activated by cell swelling. May contribute to cell volume homeostasis in single cells. Homomultimer and heteromultimer with other K-Cl cotransporters. Up-regulated by VEGF. Down-regulated by TNF. Highly expressed in heart, brain and kidney. Detected at lower levels in skeletal muscle, placenta, lung and pancreas. Detected in umbilical vein endothelial cells. Isoform 2 is more abundant in kidney. Isoform 5 is testis specific. Expressed in the proximal tubule of the kidney. Activated by N-ethylmaleimide (NEM). Inhibited by DIOA, bumetanide and furosemide. Inhibited by WNK3. Belongs to the SLC12A transporter family. 6 isoforms of the human protein are produced by alternative promoter.

Protein type: Transporter, SLC family; Membrane protein, multi-pass; Transporter; Membrane protein, integral

Chromosomal Location of Human Ortholog: 15q13

Cellular Component: basolateral plasma membrane; integral to plasma membrane; plasma membrane; integral to membrane

Molecular Function: potassium ion transmembrane transporter activity; protein kinase binding; potassium:chloride symporter activity

Biological Process: potassium ion import; ion transport; angiogenesis; transmembrane transport; potassium ion transport

Disease: Agenesis Of The Corpus Callosum With Peripheral Neuropathy

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