Full Product Name
INPP5E Antibody
Product Gene Name
anti-INPP5E antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9NRR6
Other Notes
Small volumes of anti-INPP5E antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for INPP5E. It may not necessarily be applicable to this product.
NCBI Accession #
NP_063945.2
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NCBI GenBank Nucleotide #
NM_019892.5
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UniProt Primary Accession #
Q9NRR6
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UniProt Secondary Accession #
Q15734; Q6PIV5[Other Products]
UniProt Related Accession #
Q9NRR6[Other Products]
Molecular Weight
66,193 Da
NCBI Official Full Name
72 kDa inositol polyphosphate 5-phosphatase isoform 1
NCBI Official Synonym Full Names
inositol polyphosphate-5-phosphatase E
NCBI Official Symbol
INPP5E [Similar Products]
NCBI Official Synonym Symbols
CPD4; CORS1; JBTS1; MORMS; PPI5PIV; pharbin
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NCBI Protein Information
72 kDa inositol polyphosphate 5-phosphatase
UniProt Protein Name
72 kDa inositol polyphosphate 5-phosphatase
UniProt Synonym Protein Names
Phosphatidylinositol 4,5-bisphosphate 5-phosphatase; Phosphatidylinositol polyphosphate 5-phosphatase type IV
Protein Family
72 kDa inositol polyphosphate 5-phosphatase
UniProt Gene Name
INPP5E [Similar Products]
NCBI Summary for INPP5E
The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. Studies of the mouse counterpart suggest that this protein may hydrolyze phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,5-bisphosphate on the cytoplasmic Golgi membrane and thereby regulate Golgi-vesicular trafficking. Mutations in this gene cause Joubert syndrome; a clinically and genetically heterogenous group of disorders characterized by midbrain-hindbrain malformation and various associated ciliopathies that include retinal dystrophy, nephronophthisis, liver fibrosis and polydactyly. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
UniProt Comments for INPP5E
Converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns-P2, and phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate. Specific for lipid substrates, inactive towards water soluble inositol phosphates.
Research Articles on INPP5E
1. INPP5E associates with the N-terminus of RPGR and trafficking of INPP5E to cilia is dependent upon the ciliary localization of RPGR.
Precautions
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Disclaimer
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