intraflagellar transport 122 homolog (Chlamydomonas), ELISA Kit

Human Intraflagellar transport protein 122 homolog (IFT122) ELISA kit; SPG; WDR10; WDR10p; WDR140; WD repeat domain 10; intraflagellar transport 122 homolog (Chlamydomonas)

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.

Small volumes of IFT122 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9328468 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the intraflagellar transport 122 homolog (Chlamydomonas) (IFT122) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing IFT122. The ELISA analytical biochemical technique of the MBS9328468 kit is based on IFT122 antibody-IFT122 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect IFT122 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, IFT122. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

141,825 Da

intraflagellar transport 122

intraflagellar transport protein 122 homolog; WD repeat domain 10; WD repeat-containing protein 10; WD repeat-containing protein 140; intraflagellar transport 122 homolog

Intraflagellar transport protein 122 homolog

SPG; WDR10; WDR140  [Similar Products]

IF122_HUMAN

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This cytoplasmic protein contains seven WD repeats and an AF-2 domain which function by recruiting coregulatory molecules and in transcriptional activation. Mutations in this gene cause cranioectodermal dysplasia-1. A related pseudogene is located on chromosome 3. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]

IFT122: Required for cilia formation and Shh signaling during neuronal patterning. Defects in IFT122 are a cause of cranioectodermal dysplasia type 1 (CED1). CED1 is a disorder characterized by craniofacial, skeletal and ectodermal abnormalities. Clinical features include dolichocephaly (with or without sagittal suture synostosis), scaphocephaly, short stature, limb shortening, short ribs, narrow chest, brachydactyly, renal failure and hepatic fibrosis, small and abnormally shaped teeth, sparse hair, skin laxity and abnormal nails. 4 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 3q21

Cellular Component: membrane; cytoplasm; photoreceptor connecting cilium; cilium

Molecular Function: protein binding

Biological Process: embryonic forelimb morphogenesis; signal transduction downstream of smoothened; limb development; embryonic body morphogenesis; camera-type eye morphogenesis; negative regulation of smoothened signaling pathway; organelle organization and biogenesis; neural tube closure; cilium biogenesis; embryonic heart tube development; embryonic digit morphogenesis; negative regulation of epithelial cell proliferation; negative regulation of smoothened signaling pathway in ventral spinal cord patterning

Disease: Cranioectodermal Dysplasia 1

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.