Product Name
PNKP, Blocking Peptide
Full Product Name
PNKP Peptide - middle region
Product Gene Name
PNKP blocking peptide
[Similar Products]
Product Synonym Gene Name
PNK; MCSZ; EIEE10[Similar Products]
PNKP peptide (MBS3235680) is used for blocking the activity of PNKP antibody (MBS3210725)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
ALLSASPEVV VAVGFPGAGK STFLKKHLVS AGYVHVNRDT LGSWQRCVTT
3D Structure
ModBase 3D Structure for Q96T60
Form/Format
Lyophilized powder
Preparation and Storage
Add 100ul of sterile PBS. Final peptide concentration is 1 mg/ml in PBS. For longer periods of storage, store at -20 degree C. Avoid repeat freeze-thaw cycles.
Other Notes
Small volumes of PNKP blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
PNKP blocking peptide
This is a synthetic peptide designed for use in combination with anti-PNKP Antibody, made
Target Description: This locus represents a gene involved in DNA repair. In response to ionizing radiation or oxidative damage, the protein encoded by this locus catalyzes 5' phosphorylation and 3' dephosphorylation of nucleic acids. Mutations at this locus have been associated with microcephaly, seizures, and developmental delay.
Product Categories/Family for PNKP blocking peptide
Peptide
Applications Tested/Suitable for PNKP blocking peptide
Western Blot (WB)
NCBI/Uniprot data below describe general gene information for PNKP. It may not necessarily be applicable to this product.
NCBI Accession #
NP_009185
[Other Products]
NCBI GenBank Nucleotide #
NM_007254
[Other Products]
UniProt Primary Accession #
Q96T60
[Other Products]
UniProt Related Accession #
Q96T60[Other Products]
NCBI Official Full Name
bifunctional polynucleotide phosphatase/kinase
NCBI Official Synonym Full Names
polynucleotide kinase 3'-phosphatase
NCBI Official Symbol
PNKP [Similar Products]
NCBI Official Synonym Symbols
PNK; AOA4; MCSZ; EIEE10
[Similar Products]
NCBI Protein Information
bifunctional polynucleotide phosphatase/kinase
UniProt Protein Name
Bifunctional polynucleotide phosphatase/kinase
UniProt Synonym Protein Names
DNA 5'-kinase/3'-phosphatase; Polynucleotide kinase-3'-phosphataseIncluding the following 2 domains:Polynucleotide 3'-phosphatase (EC:3.1.3.32)Alternative name(s):2'(3')-polynucleotidase
UniProt Gene Name
PNKP [Similar Products]
UniProt Entry Name
PNKP_HUMAN
NCBI Summary for PNKP
This locus represents a gene involved in DNA repair. In response to ionizing radiation or oxidative damage, the protein encoded by this locus catalyzes 5' phosphorylation and 3' dephosphorylation of nucleic acids. Mutations at this locus have been associated with microcephaly, seizures, and developmental delay.[provided by RefSeq, Sep 2010]
UniProt Comments for PNKP
Pnk1: polynucleotide kinase 3'-phosphatase. May be involved in double-strand break repair by non-homologous end joining. Required for normal response to DNA damage by gamma-radiation or camptothecin in S. pombe.
Protein type: Kinase, other; EC 3.1.3.32; EC 2.7.1.78; DNA-binding; Phosphatase (non-protein)
Chromosomal Location of Human Ortholog: 19q13.3-q13.4
Cellular Component: nucleoplasm; membrane; nucleolus; nucleus
Molecular Function: protein binding; ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity; polynucleotide 3'-phosphatase activity; purine nucleotide binding; endonuclease activity; double-stranded DNA binding; damaged DNA binding; nucleotide kinase activity; ATP binding
Biological Process: response to radiation; dephosphorylation; DNA damage response, detection of DNA damage; nucleotide-excision repair, DNA damage removal; response to oxidative stress; DNA repair; DNA-dependent DNA replication; nucleotide phosphorylation
Disease: Microcephaly, Seizures, And Developmental Delay; Ataxia-oculomotor Apraxia 4
Research Articles on PNKP
1. Despite presence of an alternative 3'-phosphatase, loss of PNKP significantly sensitizes cells to 3'-phosphate-terminated DSBs, due to a 3'-dephosphorylation defect.
Precautions
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Disclaimer
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