FRAS1 related extracellular matrix protein 2, ELISA Kit

Human FRAS1-related extracellular matrix protein 2 (FREM2) ELISA kit; DKFZp686J0811; DKFZp781I048; KIAA1074; ECM3 homolog; FRAS1-related extracellular matrix protein 2; FRAS1 related extracellular matrix protein 2

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of FREM2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9331026 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the FRAS1 related extracellular matrix protein 2 (FREM2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing FREM2. The ELISA analytical biochemical technique of the MBS9331026 kit is based on FREM2 antibody-FREM2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect FREM2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, FREM2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

351,157 Da

FRAS1 related extracellular matrix protein 2

FRAS1-related extracellular matrix protein 2; ECM3 homolog

FRAS1-related extracellular matrix protein 2

FREM2_HUMAN

This gene encodes an integral membrane protein containing numerous CSPG (chondroitin sulfate proteoglycan element) repeats and Calx-beta domains. The encoded protein localizes to the basement membrane, forming a ternary complex that plays a role in epidermal-dermal interactions. This protein is important for the integrity of skin and renal epithelia. Mutations in this gene are associated with Fraser syndrome. [provided by RefSeq, Apr 2014]

FREM2: Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia. May be required for epidermal adhesion. Defects in FREM2 are a cause of Fraser syndrome (FRASS). Fraser syndrome is a multisystem malformation usually comprising cryptophthalmos, cutaneous syndactyly, ear abnormalities, renal agenesis and congenital heart defects. Belongs to the FRAS1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Extracellular matrix; Membrane protein, integral

Chromosomal Location of Human Ortholog: 13q13.3

Cellular Component: plasma membrane; integral to membrane; basement membrane

Molecular Function: calcium ion binding

Biological Process: morphogenesis of an epithelium; cell communication; homophilic cell adhesion; inner ear development

Disease: Fraser Syndrome

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