FREM2, Polyclonal Antibody

Anti -FREM2, ID (FRAS1-related Extracellular Matrix Protein 2, ECM3 Homolog)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 13; NC_000013.10 (39261173..39461268). Location: 13q13.3

Polyclonal

Rabbit

Recognizes human FREM2. Species sequence homology: mouse.

Affinity Purified
Purified by immunoaffinity chromatography.

Supplied as a liquid in PBS, 0.02% sodium azide.

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Small volumes of anti-FREM2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia. May be required for epidermal adhesion.

Antibodies; Abs to Extracellular Matrix Proteins

ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Suitable for use in ELISA, Immunocytochemistry, Western Blot and Immunohistochemistry.
Dilution: Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml

351,157 Da[Similar Products]

FRAS1 related extracellular matrix protein 2

FRAS1-related extracellular matrix protein 2; ECM3 homolog

FRAS1-related extracellular matrix protein 2

FREM2_HUMAN

This gene encodes a membrane protein that belongs to the FRAS1 family. This extracellular matrix protein is thought to be required for maintaining the integrity of the skin epithelium and the differentiated state of renal epithelia. The protein localizes to the basement membrane, forming a ternary complex that plays a role in epidermal-dermal interactions during morphogenetic processes. Mutations in this gene are associated with Fraser syndrome. [provided by RefSeq, Jul 2008]

FREM2: Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia. May be required for epidermal adhesion. Defects in FREM2 are a cause of Fraser syndrome (FRASS). Fraser syndrome is a multisystem malformation usually comprising cryptophthalmos, cutaneous syndactyly, ear abnormalities, renal agenesis and congenital heart defects. Belongs to the FRAS1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Extracellular matrix

Chromosomal Location of Human Ortholog: 13q13.3

Cellular Component: integral to membrane; plasma membrane; basement membrane

Molecular Function: calcium ion binding

Biological Process: morphogenesis of an epithelium; cell communication; homophilic cell adhesion; inner ear development

Disease: Fraser Syndrome

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