CD36, Platelet gpIV (Thrombospondin Receptor), Monoclonal Antibody

Monoclonal Antibody to CD36 Thrombospondin Receptor

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 7; NC_000007.13 (80231504..80308593). Location: 7q11.2

Monoclonal

IgG1

FA6.152

Mouse. Hybridization of X63 Ag 8.653 myeloma cells with spleen cells from Balb/c mice.

CD36, Platelet gpIV (Thrombospondin Receptor)
The molecular weight of the recognized antigen is 90kDa. Recognizes the glycoprotein gp lllb corresponding to the thrombospondin receptor. This antibody agglutinates fetal but not ***** erythrocytes. It doe

Purified, Lyophilized
Reconstitute with 1ml distilled water.

0.2mg/ml (prior to lyophilization) (lot specific)

Store lyophilized product at 2 to 8 degree C. After reconstitution, aliquot and store at -20 degree C. Avoid multiple freeze/thaw cycles. The addition of 0.1% (w/v) sodium azide is recommended for storage of the reconstituted form for up to one month at 2

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Small volumes of anti-CD36 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Monoclonal Antibodies to Human CDs

Flow cytometry
Immunochemistry
Immunohistochemistry
Fluorescence microscopy or flow cytometry: 2ug/5 x 105 cells/test
Each laboratory should determine an optimum working titer for use in its particular application. Other applications have not

53,053 Da[Similar Products]

CD36 molecule (thrombospondin receptor)

platelet glycoprotein 4; GPIIIB; PAS IV; PAS-4 protein; glycoprotein IIIb; OTTHUMP00000207872; OTTHUMP00000207874; OTTHUMP00000207879; OTTHUMP00000207881; OTTHUMP00000207938; OTTHUMP00000229733; cluster determinant 36; fatty acid translocase; platelet glycoprotein IV; scavenger receptor class B, member 3; leukocyte differentiation antigen CD36; CD36 antigen (collagen type I receptor, thrombospondin receptor)

Platelet glycoprotein 4

GP3B; GP4  [Similar Products]

CD36_HUMAN

The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq]

Function: Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic efects. Ref.20 Ref.22

Subunit structure: Interacts with THBS1 and THBS2; the interactions mediate the THBS antiangiogenic activity. Ref.12

Subcellular location: Membrane; Multi-pass membrane protein.

Post-translational modification: N-glycosylated and O-glycosylated with a ratio of 2:1. Ref.8 Ref.14 Ref.15 Ref.16

Polymorphism: Genetic variation in CD36 influences the severity and outcome of malaria infection.

Involvement in disease: Defects in CD36 are the cause of platelet glycoprotein IV deficiency (PG4D)[

MIM:608404]; also known as CD36 deficiency. Platelet glycoprotein IV deficiency can be divided into 2 subgroups. The type I phenotype is characterized by platelets and monocytes/macrophages exhibiting complete CD36 deficiency. The type II phenotype lacks the surface expression of CD36 in platelets, but expression in monocytes/macrophages is near normal. Ref.17 Ref.21Genetic variations in CD36 are associated with susceptibility to coronary heart disease type 7 (CHDS7) [

MIM:610938]. Ref.23

Sequence similarities: Belongs to the CD36 family.

Sequence caution: The sequence AAM14636.2 differs from that shown. Reason: Frameshift at position 53.

• Edelman, P., et al., (1986), Blood, 67, No. 1 pp.56-63.

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