Product Name
Activator of apoptosis harakiri (Hrk), Recombinant Protein
Full Product Name
Recombinant Rat Activator of apoptosis harakiri (Hrk)
Product Synonym Names
Recombinant Activator of apoptosis harakiri (Hrk); Activator of apoptosis harakiri; BH3-interacting domain-containing protein 3 Neuronal death protein DP5
Product Gene Name
Hrk recombinant protein
[Similar Products]
Product Synonym Gene Name
Hrk; Bid3, Dp5[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
MCPCPRHRGR GPPAVCGCGD ARPGLRWAAA QVTALRLQAL GDELHRRAMR RRARPRDPLP ALLPALRARW PWLCAAAQVA ALAAWLLGRR SA
Chromosome Location
Chromosome: 12; NC_005111.3 (45839710..45861437, complement). Location: 12q16
3D Structure
ModBase 3D Structure for P62817
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>=90% (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Rattus norvegicus (Rat)
Preparation and Storage
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Hrk recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for Hrk. It may not necessarily be applicable to this product.
NCBI Accession #
NP_476471.1
[Other Products]
NCBI GenBank Nucleotide #
NM_057130.2
[Other Products]
UniProt Primary Accession #
P62817
[Other Products]
UniProt Secondary Accession #
P70678[Other Products]
UniProt Related Accession #
P62817[Other Products]
Molecular Weight
10,078 Da[Similar Products]
NCBI Official Full Name
activator of apoptosis harakiri
NCBI Official Synonym Full Names
harakiri, BCL2 interacting protein (contains only BH3 domain)
NCBI Official Symbol
Hrk [Similar Products]
NCBI Official Synonym Symbols
Dp5; Bid3
[Similar Products]
NCBI Protein Information
activator of apoptosis harakiri; BH3 interacting domain 3; neuronal death protein DP5; BH3-interacting domain-containing protein 3; BH3 interacting (with BCL2 family) domain, apoptosis agonist
UniProt Protein Name
Activator of apoptosis harakiri
UniProt Synonym Protein Names
BH3-interacting domain-containing protein 3; Neuronal death protein DP5
Protein Family
Activator of apoptosis harakiri
UniProt Gene Name
Hrk [Similar Products]
UniProt Synonym Gene Names
Bid3; Dp5 [Similar Products]
UniProt Entry Name
HRK_RAT
NCBI Summary for Hrk
member of the Bcl-2 family of proteins; has a role in programmed neuronal death [RGD, Feb 2006]
UniProt Comments for Hrk
HRK: Promotes apoptosis.
Protein type: Apoptosis; Membrane protein, integral
Cellular Component: mitochondrion; integral to membrane
Molecular Function: protein binding
Biological Process: cellular response to potassium ion starvation; positive regulation of protein homooligomerization; apoptosis; positive regulation of apoptosis; positive regulation of neuron apoptosis
Research Articles on Hrk
1. The inactivation of hrk protein protects -cells from IL-1beta+IFN-gamma and chemical Endoplasmic Reticulum stress-mediated cell death.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
