Product Name
Enkephalin (Penk), Peptide
Full Product Name
Enkephalin (Leu)-[D-Ser2]-Thr (DSLET, Delta-Receptor Peptide)
Product Gene Name
Penk peptide
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 5; NC_005104.3 (21834416..21839358, complement). Location: 5q12
3D Structure
ModBase 3D Structure for P04094
Purity/Purification
Highly Purified
~95%. Purified by HPLC.
Form/Format
Supplied as a lyophilized powder.
Sequence (linear)
Tyr-D-Ser-Gly-Phe-Leu-Thr
Preparation and Storage
Lyophilized powder may be stored at 4 degree C for short-term only. Stable for 12 months at -20 degree C. Reconstitute to nominal volume (see reconstitution instructions for peptides) and store at -20 degree C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.
Other Notes
Small volumes of Penk peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for Penk peptide
Molecular Biology; MB-Peptides
NCBI/Uniprot data below describe general gene information for Penk. It may not necessarily be applicable to this product.
NCBI Accession #
AAA41115.1
[Other Products]
UniProt Primary Accession #
P04094
[Other Products]
UniProt Secondary Accession #
Q53X05[Other Products]
UniProt Related Accession #
P04094[Other Products]
Molecular Weight
30,932 Da[Similar Products]
NCBI Official Full Name
enkephalin
NCBI Official Synonym Full Names
proenkephalin
NCBI Official Symbol
Penk [Similar Products]
NCBI Official Synonym Symbols
Enk; Penk1; Penk2; Penk-rs
[Similar Products]
NCBI Protein Information
proenkephalin-A; proenkephalin 1; proenkephalin 2; preproenkephalin 2; proenkephalin related sequence
UniProt Protein Name
Proenkephalin-A
UniProt Synonym Protein Names
Opioid growth factor
Protein Family
Proenkephalin
UniProt Gene Name
Penk [Similar Products]
UniProt Synonym Gene Names
Penk-rs; Penk1; OGF [Similar Products]
UniProt Entry Name
PENK_RAT
NCBI Summary for Penk
neuropeptide hormone; plays a role in the responses to stress and pain perception [RGD, Feb 2006]
UniProt Comments for Penk
Function: Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(239-260) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum. Ref.8
Subcellular location: Secreted.
Tissue specificity: Expressed in brain, heart and testis.
Post-translational modification: The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.
Sequence similarities: Belongs to the opioid neuropeptide precursor family.
Mass spectrometry: Molecular mass is 2203.971 Da from positions 114 - 133. Determined by ESI. Ref.8Molecular mass is 4592.8 Da from positions 143 - 185. Determined by ESI. Ref.8Molecular mass is 2504.027 Da from positions 239 - 260. Determined by ESI. Ref.8
Research Articles on Penk
1. enkephalin surges and mu opioid stimulation in the same anteromedial dorsal neostriatumregion contribute to signaling the opportunity to eat a sensory reward and to causally generating increased consumption of that reward.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
